|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alsoKnownAs
|
gptkb:PKB
gptkb:Protein_kinase_B_alpha
gptkb:RAC-PK-alpha
|
|
gptkbp:associatedWith
|
gptkb:cancer
gptkb:cardiovascular_disease
gptkb:diabetes
|
|
gptkbp:biologicalProcess
|
serine/threonine kinase activity
|
|
gptkbp:discoveredBy
|
gptkb:Dario_Alessi
|
|
gptkbp:discoveredIn
|
1991
|
|
gptkbp:encodes
|
gptkb:RAC-alpha_serine/threonine-protein_kinase
|
|
gptkbp:Entrez_Gene_ID
|
207
ENSG00000142208
|
|
gptkbp:function
|
cell growth regulation
metabolism regulation
cell survival regulation
apoptosis inhibition
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Akt1
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_14
|
|
gptkbp:memberOf
|
gptkb:AGC_kinase_family
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
gptkb:Akt1
|
|
gptkbp:pathway
|
gptkb:PI3K/AKT_pathway
|
|
gptkbp:phosphorylates
|
Ser473
Thr308
|
|
gptkbp:regulates
|
gptkb:TSC2
gptkb:BAD_protein
gptkb:FOXO_transcription_factors
gptkb:GSK3
gptkb:MDM2
gptkb:mTOR
gptkb:eNOS
gptkb:p27_Kip1
apoptosis
cell proliferation
translator
transcription
metabolism
angiogenesis
cell cycle progression
cell migration
glucose uptake
lipid synthesis
protein synthesis
autophagy
glycogen synthesis
GLUT4 translocation
|
|
gptkbp:UniProtID
|
gptkb:P31749
|
|
gptkbp:bfsParent
|
gptkb:Akt
gptkb:MK-2206
gptkb:triciribine
|
|
gptkbp:bfsLayer
|
7
|