Statements (31)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
protein kinase family
|
| gptkbp:activatedBy |
phosphorylation
|
| gptkbp:domain |
kinase domain
C-terminal hydrophobic motif activation loop |
| gptkbp:dysregulationAssociatedWith |
gptkb:cancer
gptkb:diabetes cardiovascular diseases neurological disorders |
| gptkbp:foundIn |
eukaryotes
|
| gptkbp:function |
phosphorylation of serine/threonine residues
|
| https://www.w3.org/2000/01/rdf-schema#label |
AGC kinase family
|
| gptkbp:includes |
gptkb:AKT_(protein_kinase_B)
gptkb:protein_kinase_C_(PKC) protein kinase A (PKA) SGK (serum- and glucocorticoid-regulated kinase) protein kinase G (PKG) ribosomal S6 kinase (RSK) |
| gptkbp:namedAfter |
PKA, PKG, PKC
|
| gptkbp:regulates |
cell proliferation
cell survival gene expression metabolism cell growth |
| gptkbp:superfamily |
protein kinases
|
| gptkbp:bfsParent |
gptkb:Akt
gptkb:RPS6KB1 gptkb:V-akt_murine_thymoma_viral_oncogene_homolog_1 gptkb:RAC-alpha_serine/threonine-protein_kinase gptkb:p70S6K |
| gptkbp:bfsLayer |
7
|