Statements (25)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:binds |
gptkb:phosphatidylinositol_(3,4,5)-trisphosphate
phosphatidylinositol (4,5)-bisphosphate |
| gptkbp:discoveredIn |
1993
|
| gptkbp:firstDescribed |
Lemmon et al.
|
| gptkbp:foundIn |
gptkb:phospholipase_C
gptkb:AKT_protein many signaling proteins pleckstrin protein |
| gptkbp:fullName |
Pleckstrin homology domain
|
| gptkbp:function |
binds phosphoinositides
mediates protein-membrane interactions |
| https://www.w3.org/2000/01/rdf-schema#label |
PH domain
|
| gptkbp:length |
approximately 120 amino acids
|
| gptkbp:namedAfter |
pleckstrin protein
|
| gptkbp:numberOfHumanProteins |
over 250
|
| gptkbp:role |
cell signaling
cytoskeletal organization membrane trafficking recruitment of proteins to membranes |
| gptkbp:structure |
beta-sandwich with a C-terminal alpha helix
|
| gptkbp:bfsParent |
gptkb:GEF
gptkb:Guanine_nucleotide_exchange_factors_(GEFs) gptkb:IRS1 |
| gptkbp:bfsLayer |
6
|