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gptkbp:instanceOf
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gptkb:protein
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gptkbp:binds
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gptkb:phosphatidylinositol_(3,4,5)-trisphosphate
phosphatidylinositol (4,5)-bisphosphate
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gptkbp:discoveredIn
|
1993
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gptkbp:firstDescribed
|
Lemmon et al.
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gptkbp:foundIn
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gptkb:phospholipase_C
gptkb:AKT_protein
many signaling proteins
pleckstrin protein
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gptkbp:fullName
|
Pleckstrin homology domain
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gptkbp:function
|
binds phosphoinositides
mediates protein-membrane interactions
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gptkbp:length
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approximately 120 amino acids
|
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gptkbp:namedAfter
|
pleckstrin protein
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gptkbp:numberOfHumanProteins
|
over 250
|
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gptkbp:role
|
cell signaling
cytoskeletal organization
membrane trafficking
recruitment of proteins to membranes
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gptkbp:structure
|
beta-sandwich with a C-terminal alpha helix
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gptkbp:bfsParent
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gptkb:AKT2
gptkb:Akt
gptkb:Ect2
gptkb:GEF
gptkb:Guanine_nucleotide_exchange_factors_(GEFs)
gptkb:PLCγ
gptkb:PLCE1
gptkb:RASA1
gptkb:RASA1_gene
gptkb:RasGAP
gptkb:SH2B3
gptkb:SOS-1_protein
gptkb:Son_of_sevenless_homolog_1
gptkb:Vav1
gptkb:Rap_guanine_nucleotide_exchange_factor_1
gptkb:PLCε
gptkb:TEC_tyrosine_kinase
gptkb:Tec_family_kinases
gptkb:BCR
gptkb:APPL1
gptkb:Dynamin_family
gptkb:SH2B1
gptkb:SH2B2
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gptkbp:bfsLayer
|
7
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https://www.w3.org/2000/01/rdf-schema#label
|
PH domain
|