|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alias
|
gptkb:AFX_(FOXO4)
gptkb:FKHR_(FOXO1)
FKHRL1 (FOXO3)
|
|
gptkbp:conservedIn
|
gptkb:metazoans
|
|
gptkbp:contains
|
gptkb:FOXO1
gptkb:FOXO3
gptkb:FOXO4
gptkb:FOXO6
|
|
gptkbp:DNABindingDomain
|
forkhead box domain
|
|
gptkbp:firstDescribed
|
1997
|
|
gptkbp:foundIn
|
animals
humans
mammals
|
|
gptkbp:fullName
|
gptkb:Forkhead_box_O
|
|
gptkbp:function
|
transcription factor
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
FOXO
|
|
gptkbp:involves
|
gptkb:cancer
gptkb:diabetes
aging
neurodegenerative diseases
|
|
gptkbp:locale
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:locatedOnChromosome
|
varies by member
|
|
gptkbp:memberOf
|
forkhead box (FOX) transcription factors
|
|
gptkbp:orthologIn
|
gptkb:DAF-16_(C._elegans)
|
|
gptkbp:phosphorylates
|
gptkb:AKT
|
|
gptkbp:proteinFamily
|
gptkb:FOXO_family
|
|
gptkbp:regulates
|
gptkb:PI3K/AKT_pathway
apoptosis
longevity
metabolism
cell cycle
insulin signaling pathway
oxidative stress resistance
|
|
gptkbp:relatedTo
|
insulin/IGF-1 signaling
|
|
gptkbp:targetGene
|
gptkb:GADD45
gptkb:BNIP3
gptkb:FasL
gptkb:IGFBP-1
gptkb:LC3
gptkb:MnSOD
gptkb:Sestrin3
gptkb:p27Kip1
BIM
catalase
|
|
gptkbp:transcriptionalActivity
|
regulated by phosphorylation
regulated by acetylation
regulated by ubiquitination
|
|
gptkbp:bfsParent
|
gptkb:AKT_pathway
gptkb:FOXO_transcription_factors
gptkb:PI3K-Akt_signaling_pathway
|
|
gptkbp:bfsLayer
|
6
|