Statements (34)
Predicate | Object |
---|---|
gptkbp:instanceOf |
biological pathway
|
gptkbp:activatedBy |
gptkb:insulin
gptkb:receptor_tyrosine_kinases growth factors |
gptkbp:alsoKnownAs |
phosphoinositide 3-kinase pathway
|
gptkbp:cause |
AKT activation
PIP3 production mTOR activation |
gptkbp:component |
p110 catalytic subunit
p85 regulatory subunit |
gptkbp:downstreamOf |
gptkb:G_protein-coupled_receptors
gptkb:receptor_tyrosine_kinases |
gptkbp:dysregulationAssociatedWith |
gptkb:cancer
gptkb:diabetes autoimmune diseases |
gptkbp:firstDescribed |
1980s
|
https://www.w3.org/2000/01/rdf-schema#label |
PI3K pathway
|
gptkbp:inhibitedBy |
gptkb:LY294002
gptkb:wortmannin PI3K inhibitors |
gptkbp:involves |
gptkb:AKT
gptkb:mTOR PI3K enzyme |
gptkbp:negativelyRegulatedBy |
gptkb:PTEN
gptkb:SHIP |
gptkbp:regulates |
cell proliferation
cell survival metabolism cell growth |
gptkbp:studiedIn |
oncology
metabolic research |
gptkbp:bfsParent |
gptkb:PI3K/AKT/mTOR_pathway
gptkb:Jean_Zhao |
gptkbp:bfsLayer |
5
|