Statements (33)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:biological_pathway
|
| gptkbp:activatedBy |
gptkb:insulin
gptkb:receptor_tyrosine_kinases growth factors |
| gptkbp:alsoKnownAs |
phosphoinositide 3-kinase pathway
|
| gptkbp:cause |
AKT activation
PIP3 production mTOR activation |
| gptkbp:component |
p110 catalytic subunit
p85 regulatory subunit |
| gptkbp:downstreamOf |
gptkb:G_protein-coupled_receptors
gptkb:receptor_tyrosine_kinases |
| gptkbp:dysregulationAssociatedWith |
gptkb:cancer
gptkb:diabetes autoimmune diseases |
| gptkbp:firstDescribed |
1980s
|
| gptkbp:inhibitedBy |
gptkb:LY294002
gptkb:wortmannin PI3K inhibitors |
| gptkbp:involves |
gptkb:AKT
gptkb:mTOR PI3K enzyme |
| gptkbp:negativelyRegulatedBy |
gptkb:PTEN
gptkb:SHIP |
| gptkbp:regulates |
cell proliferation
cell survival metabolism cell growth |
| gptkbp:studiedIn |
oncology
metabolic research |
| gptkbp:bfsParent |
gptkb:Jean_Zhao
|
| gptkbp:bfsLayer |
5
|
| https://www.w3.org/2000/01/rdf-schema#label |
PI3K pathway
|