retinoblastoma susceptibility protein

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:protein
gptkbp:alsoKnownAs	gptkb:RB_protein
gptkbp:associatedWith	hereditary cancer syndromes
gptkbp:binds	gptkb:E2F1 gptkb:HDAC1 LXCXE motif-containing proteins
gptkbp:degradedBy	gptkb:ubiquitin-proteasome_pathway
gptkbp:dephosphorylatedBy	gptkb:protein_phosphatase_1
gptkbp:discoveredBy	gptkb:Weinberg_lab
gptkbp:domain	pocket domain
gptkbp:encodedBy	gptkb:RB1_gene
gptkbp:Entrez_Gene_ID	gptkb:RB1
gptkbp:expressedIn	most human tissues
gptkbp:firstDescribed	1986
gptkbp:foundIn	gptkb:Homo_sapiens
gptkbp:function	tumor suppressor
https://www.w3.org/2000/01/rdf-schema#label	retinoblastoma susceptibility protein
gptkbp:inhibitedBy	gptkb:E2F_transcription_factors
gptkbp:interactsWith	gptkb:BRG1 gptkb:MDM2 gptkb:Cyclin_D1 gptkb:DP1 gptkb:p53
gptkbp:involvedIn	cell cycle regulation
gptkbp:locatedIn	gptkb:nucleus
gptkbp:locatedOnChromosome	13q14.2
gptkbp:molecularWeight	~110 kDa
gptkbp:mutationAssociatedWith	gptkb:small_cell_lung_carcinoma gptkb:retinoblastoma osteosarcoma
gptkbp:OMIM	614041
gptkbp:orthologIn	gptkb:Mus_musculus gptkb:Drosophila_melanogaster
gptkbp:PDB	gptkb:1GUX 2QDJ
gptkbp:phosphorylates	gptkb:cyclin-dependent_kinases
gptkbp:postTranslationalModification	phosphorylation ubiquitination acetylation
gptkbp:regulates	apoptosis cell differentiation G1/S cell cycle transition chromatin remodeling
gptkbp:target	gptkb:SV40_large_T_antigen gptkb:adenovirus_E1A_protein oncogenic viruses human papillomavirus E7 protein
gptkbp:UniProtID	P06400
gptkbp:bfsParent	gptkb:RB_protein
gptkbp:bfsLayer	8