retinoblastoma protein (pRb)

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:protein
gptkbp:alternativeName	gptkb:RB_protein p105-Rb
gptkbp:decommissioned	gptkb:HPV_E7_protein gptkb:SV40_large_T_antigen gptkb:adenovirus_E1A_protein
gptkbp:dephosphorylatedBy	gptkb:protein_phosphatase_1
gptkbp:discoveredBy	gptkb:Brenda_Gallie
gptkbp:discoveredIn	1986
gptkbp:encodedBy	gptkb:RB1_gene
gptkbp:Entrez_Gene_ID	gptkb:RB1
gptkbp:foundIn	gptkb:Homo_sapiens
gptkbp:function	gptkb:tumor_suppressor
gptkbp:inhibitedBy	gptkb:E2F_transcription_factors
gptkbp:interactsWith	gptkb:MDM2 gptkb:BRCA1 gptkb:Cyclin_D1 gptkb:E2F1 gptkb:HDAC1 gptkb:p53
gptkbp:locale	gptkb:nucleus
gptkbp:locatedOnChromosome	13q14.2
gptkbp:molecularWeight	~110 kDa
gptkbp:mutationAssociatedWith	gptkb:small_cell_lung_carcinoma gptkb:retinoblastoma osteosarcoma
gptkbp:phosphorylates	cyclin-dependent kinases (CDKs)
gptkbp:regulates	cell cycle
gptkbp:requires	apoptosis regulation cellular differentiation chromatin remodeling
gptkbp:role	G1/S cell cycle checkpoint
gptkbp:structure	contains pocket domain
gptkbp:UniProtID	P06400
gptkbp:bfsParent	gptkb:Cyclin-dependent_kinase_4 gptkb:Cyclin-dependent_kinase_6 gptkb:SV40_large_T_antigen gptkb:Cyclin_D_protein
gptkbp:bfsLayer	8
https://www.w3.org/2000/01/rdf-schema#label	retinoblastoma protein (pRb)