retinoblastoma protein (pRb)

URI: https://gptkb.org/entity/retinoblastoma_protein_(pRb)
GPTKB entity
Statements (37)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkbp:alternativeName gptkb:RB_protein
p105-Rb
gptkbp:decommissioned gptkb:HPV_E7_protein
gptkb:SV40_large_T_antigen
gptkb:adenovirus_E1A_protein
gptkbp:dephosphorylatedBy gptkb:protein_phosphatase_1
gptkbp:discoveredBy gptkb:Brenda_Gallie
gptkbp:discoveredIn 1986
gptkbp:encodedBy gptkb:RB1_gene
gptkbp:Entrez_Gene_ID gptkb:RB1
gptkbp:foundIn gptkb:Homo_sapiens
gptkbp:function tumor suppressor
https://www.w3.org/2000/01/rdf-schema#label retinoblastoma protein (pRb)
gptkbp:inhibitedBy gptkb:E2F_transcription_factors
gptkbp:interactsWith gptkb:MDM2
gptkb:BRCA1
gptkb:Cyclin_D1
gptkb:E2F1
gptkb:HDAC1
gptkb:p53
gptkbp:locale gptkb:nucleus
gptkbp:locatedOnChromosome 13q14.2
gptkbp:molecularWeight ~110 kDa
gptkbp:mutationAssociatedWith gptkb:small_cell_lung_carcinoma
gptkb:retinoblastoma
osteosarcoma
gptkbp:phosphorylates cyclin-dependent kinases (CDKs)
gptkbp:regulates cell cycle
gptkbp:requires apoptosis regulation
cellular differentiation
chromatin remodeling
gptkbp:role G1/S cell cycle checkpoint
gptkbp:structure contains pocket domain
gptkbp:UniProtID P06400
gptkbp:bfsParent gptkb:Cyclin_D
gptkbp:bfsLayer 7