Cyclin-dependent kinase 4

URI: https://gptkb.org/entity/Cyclin-dependent_kinase_4

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:protein gptkb:enzyme
gptkbp:alias	gptkb:PSK-J3 gptkb:cell_division_protein_kinase_4 gptkb:CDK4
gptkbp:associatedWith	gptkb:cancer gptkb:glioblastoma melanoma
gptkbp:discoveredBy	1992
gptkbp:EC_number	2.7.11.22
gptkbp:Entrez_Gene_ID	gptkb:ENSG00000135446
gptkbp:expressedIn	many tissues
gptkbp:formsComplexWith	gptkb:Cyclin_D2 gptkb:Cyclin_D3 gptkb:Cyclin_D1
gptkbp:function	cell cycle regulation serine/threonine kinase activity
gptkbp:gene	gptkb:CDK4
gptkbp:GO_term	GO:0004693
gptkbp:HGNC_ID	1773
https://www.w3.org/2000/01/rdf-schema#label	Cyclin-dependent kinase 4
gptkbp:inhibitedBy	gptkb:p15INK4b gptkb:p16INK4a gptkb:p18INK4c gptkb:p19INK4d
gptkbp:locatedOnChromosome	12q14
gptkbp:molecularWeight	34 kDa
gptkbp:OMIM	123829
gptkbp:orthologInMouse	gptkb:Cdk4
gptkbp:PDB	gptkb:2W96
gptkbp:phosphorylates	gptkb:retinoblastoma_protein_(pRb)
gptkbp:product	gptkb:CDK4_gene
gptkbp:RefSeq	NP_000066.1
gptkbp:regulates	G1 phase of cell cycle
gptkbp:structure	monomer
gptkbp:targetOfDrug	gptkb:palbociclib gptkb:ribociclib gptkb:abemaciclib
gptkbp:UniProtID	P11802
gptkbp:bfsParent	gptkb:HGNC:1784 gptkb:CDK4
gptkbp:bfsLayer	7