Cyclin-dependent kinase 6

URI: https://gptkb.org/entity/Cyclin-dependent_kinase_6

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:protein gptkb:enzyme
gptkbp:alternativeName	gptkb:cell_division_protein_kinase_6 gptkb:cyclin-dependent_kinase_6 gptkb:CDK6
gptkbp:associatedWith	gptkb:cancer leukemia
gptkbp:biologicalProcess	serine/threonine kinase activity
gptkbp:EC_number	2.7.11.22
gptkbp:encodedBy	gptkb:CDK6_gene
gptkbp:Entrez_Gene_ID	1021
gptkbp:expressedIn	gptkb:testis brain hematopoietic cells
gptkbp:function	regulation of cell cycle G1 phase progression
gptkbp:HGNC_ID	1777
https://www.w3.org/2000/01/rdf-schema#label	Cyclin-dependent kinase 6
gptkbp:inhibitedBy	gptkb:p16INK4a gptkb:palbociclib gptkb:ribociclib gptkb:abemaciclib
gptkbp:interactsWith	gptkb:cyclin_D1 gptkb:cyclin_D2 gptkb:cyclin_D3
gptkbp:locatedOnChromosome	gptkb:7q21.2
gptkbp:location	gptkb:nucleus gptkb:cytoplasm
gptkbp:molecularWeight	36 kDa
gptkbp:mutationAssociatedWith	gptkb:medulloblastoma gptkb:glioblastoma leukemia
gptkbp:organism	gptkb:Homo_sapiens
gptkbp:orthologInMouse	gptkb:Cdk6
gptkbp:pathway	p53 signaling pathway cell cycle pathway
gptkbp:PDB	gptkb:1G3N
gptkbp:phosphorylates	gptkb:retinoblastoma_protein_(pRb)
gptkbp:postTranslationalModification	phosphorylation ubiquitination acetylation
gptkbp:product	gptkb:CDK6_gene
gptkbp:regulates	cell differentiation cell proliferation
gptkbp:UniProtID	gptkb:Q00534
gptkbp:bfsParent	gptkb:CDK6
gptkbp:bfsLayer	7