|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:activatedBy
|
gptkb:phosphoinositide_3-kinase_(PI3K)_pathway
phosphorylation
|
|
gptkbp:alsoKnownAs
|
gptkb:PKB
gptkb:AKT
|
|
gptkbp:associatedWith
|
gptkb:cancer
gptkb:cardiovascular_disease
gptkb:diabetes_mellitus
neurodegenerative disease
|
|
gptkbp:discoveredBy
|
gptkb:Philip_Cohen
gptkb:Dario_Alessi
|
|
gptkbp:discoveredIn
|
1991
|
|
gptkbp:domain
|
gptkb:pleckstrin_homology_domain
kinase domain
regulatory domain
|
|
gptkbp:encodedBy
|
gptkb:AKT1
gptkb:AKT2
gptkb:AKT3
|
|
gptkbp:function
|
regulation of apoptosis
regulation of cell proliferation
regulation of cell survival
regulation of cell growth
serine/threonine kinase activity
regulation of glucose metabolism
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
protein kinase B (AKT)
|
|
gptkbp:inhibitedBy
|
gptkb:PTEN
phosphatases
|
|
gptkbp:locale
|
gptkb:nucleus
gptkb:cytoplasm
gptkb:plasma_membrane
|
|
gptkbp:molecularWeight
|
~56 kDa
|
|
gptkbp:phosphorylates
|
Ser473
Thr308
|
|
gptkbp:proteinFamily
|
gptkb:AKT_family
|
|
gptkbp:regulates
|
gptkb:GSK-3
gptkb:TSC2
gptkb:CREB
gptkb:p21
gptkb:BAD_protein
gptkb:FOXO_transcription_factors
gptkb:MDM2
gptkb:mTOR_pathway
gptkb:NF-κB
gptkb:eNOS
gptkb:p27_Kip1
lipid metabolism
angiogenesis
cell cycle progression
protein synthesis
glycogen synthesis
GLUT4 translocation
|
|
gptkbp:bfsParent
|
gptkb:PIP3
|
|
gptkbp:bfsLayer
|
7
|