Statements (32)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:activatedBy |
gptkb:phosphoinositide_3-kinase_(PI3K)_pathway
|
| gptkbp:alsoKnownAs |
gptkb:Protein_kinase_B_family
|
| gptkbp:discoveredBy |
multiple researchers in the 1990s
|
| gptkbp:domain |
gptkb:pleckstrin_homology_domain
regulatory domain protein kinase domain |
| gptkbp:foundIn |
animals
|
| gptkbp:function |
serine/threonine kinase activity
|
| https://www.w3.org/2000/01/rdf-schema#label |
AKT family
|
| gptkbp:involvedIn |
cell proliferation
cell survival cell growth metabolism regulation apoptosis inhibition |
| gptkbp:involves |
gptkb:cancer
gptkb:diabetes cardiovascular diseases neurological disorders |
| gptkbp:locatedOnChromosome |
chromosome 1 (AKT3)
chromosome 14 (AKT1) chromosome 19 (AKT2) |
| gptkbp:member |
gptkb:AKT1
gptkb:AKT2 gptkb:AKT3 |
| gptkbp:orthologIn |
gptkb:Caenorhabditis_elegans_(akt-1,_akt-2)
gptkb:Drosophila_melanogaster_(dAkt) |
| gptkbp:target |
anticancer drugs
small molecule inhibitors |
| gptkbp:bfsParent |
gptkb:AKT_(protein_kinase_B)
gptkb:AKT |
| gptkbp:bfsLayer |
6
|