phosphoinositide 3-kinase (PI3K) pathway
GPTKB entity
Statements (29)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
signaling molecule
|
| gptkbp:activatedBy |
gptkb:G_protein-coupled_receptors
gptkb:receptor_tyrosine_kinases |
| gptkbp:component |
gptkb:PIP3
gptkb:AKT gptkb:PDK1 gptkb:PTEN gptkb:mTOR gptkb:PIP2 |
| gptkbp:discoveredBy |
gptkb:Lewis_Cantley
|
| gptkbp:discoveredIn |
1988
|
| gptkbp:downstreamOf |
gptkb:AKT
gptkb:mTOR |
| https://www.w3.org/2000/01/rdf-schema#label |
phosphoinositide 3-kinase (PI3K) pathway
|
| gptkbp:involves |
gptkb:phosphoinositide_3-kinase_(PI3K)
gptkb:cancer gptkb:diabetes autoimmune diseases |
| gptkbp:location |
gptkb:cytoplasm
gptkb:plasma_membrane |
| gptkbp:negativelyRegulatedBy |
gptkb:PTEN
|
| gptkbp:regulates |
cell proliferation
cell survival cell growth cell metabolism |
| gptkbp:target |
PI3K inhibitors
|
| gptkbp:bfsParent |
gptkb:AKT_(protein_kinase_B)
gptkb:AKT |
| gptkbp:bfsLayer |
6
|