|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:Ras_oncogene_protein
gptkb:Ras_p21
gptkb:Ras_protein
|
|
gptkbp:binds
|
gptkb:GDP
gptkb:GTP
|
|
gptkbp:discoveredBy
|
gptkb:Robert_Weinberg
gptkb:Michael_Wigler
|
|
gptkbp:encodedBy
|
gptkb:HRAS_gene
gptkb:NRAS_gene
gptkb:KRAS_gene
|
|
gptkbp:firstDescribed
|
1982
|
|
gptkbp:form
|
GTP-bound
|
|
gptkbp:function
|
guanine nucleotide exchange factor
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
p21ras
|
|
gptkbp:inactiveForm
|
GDP-bound
|
|
gptkbp:involvedIn
|
cell differentiation
cell proliferation
cell signaling
oncogenesis
|
|
gptkbp:locale
|
gptkb:plasma_membrane
|
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gptkbp:memberOf
|
gptkb:Ras_superfamily
|
|
gptkbp:molecularWeight
|
21 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:cancer
colorectal cancer
pancreatic cancer
|
|
gptkbp:orthologIn
|
gptkb:C._elegans_let-60
gptkb:Drosophila_Ras85D
|
|
gptkbp:PDB
|
gptkb:5P21
4Q21
|
|
gptkbp:postTranslationalModification
|
farnesylation
palmitoylation
|
|
gptkbp:regulates
|
gptkb:GDIs_(guanine_nucleotide_dissociation_inhibitors)
gptkb:MAPK_pathway
gptkb:PI3K_pathway
gptkb:GAPs_(GTPase-activating_proteins)
gptkb:GEFs_(guanine_nucleotide_exchange_factors)
cell cycle
|
|
gptkbp:species
|
gptkb:Mus_musculus
gptkb:Homo_sapiens
gptkb:Rattus_norvegicus
|
|
gptkbp:structure
|
G domain
switch I region
switch II region
|
|
gptkbp:UniProtID
|
gptkb:P01111
gptkb:P01112
gptkb:P01116
|
|
gptkbp:bfsParent
|
gptkb:Transforming_protein_p21
gptkb:transforming_protein_p21
|
|
gptkbp:bfsLayer
|
6
|