GEFs (guanine nucleotide exchange factors)
GPTKB entity
Statements (47)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:discoveredBy |
1980s
|
| gptkbp:domain |
DH (Dbl homology) domain
PH (Pleckstrin homology) domain |
| gptkbp:example |
gptkb:C3G
gptkb:Dbl gptkb:Dock180 gptkb:Ect2 gptkb:Epac gptkb:RasGRP gptkb:Tiam1 gptkb:Vav1 gptkb:SOS1 Intersectin |
| gptkbp:function |
activate small GTPases
|
| https://www.w3.org/2000/01/rdf-schema#label |
GEFs (guanine nucleotide exchange factors)
|
| gptkbp:involved_in_disease |
gptkb:cancer
neurological disorders immune disorders |
| gptkbp:locale |
gptkb:nucleus
gptkb:Golgi_apparatus gptkb:cytoplasm gptkb:plasma_membrane |
| gptkbp:mechanismOfAction |
facilitate exchange of GDP for GTP
|
| gptkbp:opposedBy |
gptkb:Guanine_nucleotide_dissociation_inhibitors_(GDIs)
GTPase-activating proteins (GAPs) |
| gptkbp:regulates |
cell differentiation
cell proliferation vesicle trafficking autoinhibition phosphorylation protein-protein interactions cell signaling pathways cytoskeletal dynamics lipid binding second messengers |
| gptkbp:studiedBy |
biochemistry
cancer research cell biology molecular biology neuroscience |
| gptkbp:target |
Arf family GTPases
Rab family GTPases Ras family GTPases Rho family GTPases |
| gptkbp:bfsParent |
gptkb:HRAS
|
| gptkbp:bfsLayer |
5
|