|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:activatedBy
|
guanine nucleotide exchange factors (GEFs)
|
|
gptkbp:associatedWith
|
gptkb:cancer
colorectal cancer
melanoma
pancreatic cancer
|
|
gptkbp:binds
|
gptkb:GDP
gptkb:GTP
|
|
gptkbp:decommissioned
|
GTPase-activating proteins (GAPs)
|
|
gptkbp:discoveredIn
|
1980s
|
|
gptkbp:encodedBy
|
gptkb:RAS_gene
|
|
gptkbp:foundIn
|
gptkb:Homo_sapiens
|
|
gptkbp:function
|
GTPase activity
|
|
gptkbp:hasIsoform
|
gptkb:HRAS
gptkb:KRAS
gptkb:NRAS
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Ras oncogene protein
|
|
gptkbp:involvedIn
|
cell differentiation
cell proliferation
cell signal transduction
|
|
gptkbp:locale
|
gptkb:plasma_membrane
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_11_(HRAS)
gptkb:chromosome_12_(KRAS)
gptkb:chromosome_1_(NRAS)
|
|
gptkbp:memberOf
|
gptkb:Ras_superfamily
|
|
gptkbp:molecularWeight
|
~21 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:cancer
codon 12
codon 13
codon 61
|
|
gptkbp:namedAfter
|
gptkb:rat_sarcoma_virus
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Caenorhabditis_elegans
gptkb:Drosophila_melanogaster
|
|
gptkbp:PDB
|
gptkb:5P21
|
|
gptkbp:postTranslationalModification
|
farnesylation
palmitoylation
|
|
gptkbp:regulates
|
gptkb:MAPK/ERK_pathway
gptkb:PI3K/AKT_pathway
|
|
gptkbp:structure
|
G domain
|
|
gptkbp:subfamily
|
small molecule
|
|
gptkbp:target
|
gptkb:KRAS_G12C_inhibitors
farnesyltransferase inhibitors
anticancer drug research
|
|
gptkbp:UniProtID
|
gptkb:P01112
|
|
gptkbp:bfsParent
|
gptkb:p21ras
|
|
gptkbp:bfsLayer
|
7
|