|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:activatedBy
|
guanine nucleotide exchange factors (GEFs)
|
|
gptkbp:alias
|
gptkb:Ras_GTPase
gptkb:Rat_sarcoma_protein
|
|
gptkbp:associatedWith
|
gptkb:cancer
colorectal cancer
pancreatic cancer
|
|
gptkbp:binds
|
gptkb:GDP
gptkb:GTP
|
|
gptkbp:decommissioned
|
GTPase-activating proteins (GAPs)
|
|
gptkbp:discoveredBy
|
gptkb:Christopher_Marshall
gptkb:Robin_Weiss
|
|
gptkbp:discoveredIn
|
1982
|
|
gptkbp:encodedBy
|
gptkb:RAS_gene_family
|
|
gptkbp:foundIn
|
animals
humans
|
|
gptkbp:function
|
signal transduction
GTPase activity
|
|
gptkbp:gene
|
gptkb:HRAS
gptkb:KRAS
gptkb:NRAS
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Ras protein
|
|
gptkbp:involvedIn
|
cell differentiation
cell survival
cell growth regulation
|
|
gptkbp:location
|
gptkb:cell_membrane
|
|
gptkbp:memberOf
|
gptkb:small_GTPase_superfamily
|
|
gptkbp:molecularWeight
|
~21 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:cancer
|
|
gptkbp:orthologIn
|
gptkb:Caenorhabditis_elegans
gptkb:Drosophila_melanogaster
|
|
gptkbp:PDB
|
gptkb:5P21
|
|
gptkbp:postTranslationalModification
|
farnesylation
palmitoylation
prenylation
|
|
gptkbp:regulates
|
gptkb:Ral-GDS_pathway
gptkb:MAPK/ERK_pathway
gptkb:PI3K/AKT_pathway
|
|
gptkbp:structure
|
contains G domain
|
|
gptkbp:subfamily
|
gptkb:K-Ras
gptkb:H-Ras
gptkb:N-Ras
|
|
gptkbp:target
|
biological research
anticancer drugs
|
|
gptkbp:UniProtID
|
gptkb:P01111
gptkb:P01112
gptkb:P01116
|
|
gptkbp:bfsParent
|
gptkb:RalGEF_pathway
gptkb:RAS_gene
gptkb:G_protein-coupled_receptor
|
|
gptkbp:bfsLayer
|
5
|