Statements (61)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:protein
|
| gptkbp:bfsLayer |
5
|
| gptkbp:bfsParent |
gptkb:Raf_kinase
|
| gptkbp:associated_with |
gptkb:healthcare_organization
|
| gptkbp:constructed_in |
gptkb:Person
mice rats |
| gptkbp:discontinued |
Ras GAP
|
| gptkbp:discovered_by |
gptkb:1980s
M. Wigler |
| gptkbp:established |
gptkb:Adagrasib
MAPK pathway growth factors Sotorasib Ras inhibitors |
| gptkbp:family |
small GT Pase
|
| gptkbp:function |
cell signaling
|
| gptkbp:genetic_diversity |
H-Ras mutation
K-Ras mutation N-Ras mutation |
| https://www.w3.org/2000/01/rdf-schema#label |
Ras protein
|
| gptkbp:interacts_with |
RAF kinase
P I3 K Ras GAP |
| gptkbp:is_aimed_at |
gptkb:vaccine
chemotherapy targeted therapy |
| gptkbp:is_essential_for |
normal cell function
|
| gptkbp:is_involved_in |
gptkb:Company
gptkb:psychologist aging cell differentiation cell growth developmental processes immune response metabolic processes signal transduction inflammation metabolic syndrome obesity wound healing cardiovascular diseases cell communication cell survival neurogenesis tissue repair stem cell maintenance |
| gptkbp:is_linked_to |
gptkb:healthcare_organization
|
| gptkbp:is_part_of |
Ras signaling pathway
|
| gptkbp:is_studied_in |
molecular biology
biochemistry cell biology cancer research |
| gptkbp:regulates |
cell cycle
apoptosis gene expression |
| gptkbp:role |
tumorigenesis
angiogenesis metastasis |
| gptkbp:type |
GTP-binding protein
molecular switch |