mechanistic target of rapamycin pathway

GPTKB entity

Predicate	Object
gptkbp:instanceOf	biological pathway
gptkbp:activatedBy	gptkb:insulin growth factors amino acids energy status
gptkbp:alsoKnownAs	gptkb:mTOR_pathway
gptkbp:component	gptkb:Deptor gptkb:PRAS40 gptkb:mLST8 gptkb:bird gptkb:mTORC1 gptkb:mTORC2 gptkb:Rictor
gptkbp:discoveredBy	gptkb:David_Sabatini
gptkbp:discoveredIn	1994
gptkbp:downstreamOf	gptkb:4EBP1 gptkb:HIF-1α gptkb:S6K1 gptkb:ULK1
gptkbp:dysregulationAssociatedWith	gptkb:cancer gptkb:diabetes aging neurodegenerative diseases
https://www.w3.org/2000/01/rdf-schema#label	mechanistic target of rapamycin pathway
gptkbp:inhibitedBy	gptkb:rapamycin gptkb:AMPK gptkb:hypoxia nutrient deprivation
gptkbp:location	gptkb:lysosome gptkb:cytoplasm
gptkbp:regulates	cell proliferation cell survival transcription cell growth protein synthesis autophagy cell motility
gptkbp:relatedTo	autophagy pathway insulin signaling pathway TOR signaling pathway
gptkbp:target	gptkb:everolimus gptkb:rapamycin gptkb:sirolimus gptkb:temsirolimus gptkb:ridaforolimus
gptkbp:upregulatedBy	gptkb:PI3K gptkb:AKT
gptkbp:bfsParent	gptkb:mTOR_pathway
gptkbp:bfsLayer	5