insulin-like growth factor 1 receptor

URI: https://gptkb.org/entity/insulin-like_growth_factor_1_receptor
GPTKB entity
Statements (48)
Predicate Object
gptkbp:instanceOf gptkb:receptor_tyrosine_kinase
gptkb:protein
gptkbp:alternativeName gptkb:IGF-1R
gptkb:CD221
gptkbp:associatedWith gptkb:cancer
growth disorders
gptkbp:biologicalProcess receptor tyrosine kinase activity
gptkbp:cellularComponent gptkb:plasma_membrane
gptkbp:Entrez_Gene_ID gptkb:ENSG00000140443
gptkbp:expressedIn many tissues
gptkbp:formsComplexWith gptkb:insulin_receptor
gptkbp:foundIn gptkb:Homo_sapiens
gptkbp:function regulates cell differentiation
regulates cell survival
regulates cell growth
mediates effects of IGF-1
gptkbp:gene gptkb:IGF1R
gptkbp:HGNC_ID 5465
https://www.w3.org/2000/01/rdf-schema#label insulin-like growth factor 1 receptor
gptkbp:inhibitedBy gptkb:linsitinib
gptkb:picropodophyllin
gptkbp:interactsWith gptkb:PIK3R1
gptkb:SHC1
gptkb:SOCS_proteins
gptkb:IRS1
GRB10
gptkbp:ligand gptkb:insulin-like_growth_factor_2
gptkb:insulin-like_growth_factor_1
gptkbp:locatedOnChromosome chromosome 15q26.3
gptkbp:mutationAssociatedWith insulin resistance
growth retardation
gptkbp:OMIM 147370
gptkbp:orthologInMouse gptkb:Igf1r
gptkbp:PDB 5U8R
gptkbp:phosphorylates tyrosine residues
gptkbp:postTranslationalModification phosphorylation
glycosylation
gptkbp:role embryonic development
metabolic regulation
apoptosis inhibition
gptkbp:structure heterotetramer
gptkbp:subunit alpha subunit
beta subunit
gptkbp:target therapeutic antibodies
small molecule inhibitors
gptkbp:UniProtID gptkb:P08069
gptkbp:bfsParent gptkb:receptor_tyrosine_kinases_(Class_IA)
gptkbp:bfsLayer 6