|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
gptkb:IGF-1R
gptkb:CD221
gptkb:IGFIR
JTK13B
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:biologicalProcess
|
regulation of apoptosis
regulation of cell proliferation
protein tyrosine kinase activity
metabolic process
|
|
gptkbp:cellularComponent
|
gptkb:plasma_membrane
|
|
gptkbp:discoveredBy
|
LeRoith et al.
|
|
gptkbp:discoveredIn
|
1980s
|
|
gptkbp:encodes
|
IGF-1R protein
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000140443
3480
|
|
gptkbp:fullName
|
gptkb:insulin-like_growth_factor_1_receptor
|
|
gptkbp:function
|
gptkb:receptor_tyrosine_kinase
mediates effects of IGF-1
|
|
gptkbp:HGNC_ID
|
5465
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Igf1r
|
|
gptkbp:interactsWith
|
insulin-like growth factor 1 (IGF-1)
insulin-like growth factor 2 (IGF-2)
insulin receptor (INSR)
|
|
gptkbp:locatedOnChromosome
|
19
|
|
gptkbp:location
|
gptkb:19p13.2
|
|
gptkbp:mutationAssociatedWith
|
growth disorders
|
|
gptkbp:OMIM
|
147370
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
gptkb:Igf1r
|
|
gptkbp:pathway
|
gptkb:MAPK_signaling_pathway
gptkb:PI3K-Akt_signaling_pathway
|
|
gptkbp:proteinFamily
|
insulin receptor family
|
|
gptkbp:relatedTo
|
gptkb:cancer
cell survival
cell growth
|
|
gptkbp:significance
|
target in cancer therapy
|
|
gptkbp:target
|
therapeutic antibodies
small molecule inhibitors
|
|
gptkbp:UniProtID
|
gptkb:P08069
|
|
gptkbp:bfsParent
|
gptkb:chromosome_15_(mouse)
gptkb:insulin-like_growth_factor_1_receptor
|
|
gptkbp:bfsLayer
|
7
|