|
gptkbp:instanceOf
|
gptkb:receptor_tyrosine_kinase
gptkb:protein
|
|
gptkbp:alternativeSplicing
|
produces isoforms IR-A and IR-B
|
|
gptkbp:associatedWith
|
gptkb:type_2_diabetes
insulin resistance
|
|
gptkbp:binds
|
gptkb:insulin
|
|
gptkbp:discoveredBy
|
gptkb:Ora_Rosen
|
|
gptkbp:domain
|
extracellular domain
transmembrane domain
intracellular tyrosine kinase domain
|
|
gptkbp:EC_number
|
2.7.10.1
|
|
gptkbp:encodedBy
|
gptkb:INSR_gene
|
|
gptkbp:expressedIn
|
gptkb:skeletal_muscle
liver
adipose tissue
|
|
gptkbp:formsComplexWith
|
gptkb:insulin-like_growth_factor_1_receptor_(IGF1R)
|
|
gptkbp:foundIn
|
gptkb:cell_membrane
|
|
gptkbp:function
|
mediates cellular response to insulin
regulates glucose uptake
|
|
gptkbp:hasBiologicalActivity
|
gptkb:receptor_tyrosine_kinase
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
insulin receptor
|
|
gptkbp:inhibitedBy
|
monoclonal antibodies
small molecule inhibitors
|
|
gptkbp:initiatesPathway
|
gptkb:MAPK_signaling_pathway
gptkb:PI3K-Akt_signaling_pathway
|
|
gptkbp:interactsWith
|
gptkb:PIK3R1
gptkb:SHC1
gptkb:PTPN1
gptkb:GRB2
gptkb:IRS1
gptkb:IRS2
|
|
gptkbp:ligand
|
gptkb:insulin
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_19p13.2
|
|
gptkbp:molecularWeight
|
~320 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:insulin_resistance_syndromes
|
|
gptkbp:OMIM
|
147670
|
|
gptkbp:orthologIn
|
gptkb:entomologist
gptkb:mouse
gptkb:zebrafish
right
|
|
gptkbp:PDB
|
gptkb:3LOH
|
|
gptkbp:phosphorylates
|
gptkb:insulin_receptor_substrate_(IRS)_proteins
itself (autophosphorylation)
|
|
gptkbp:postTranslationalModification
|
phosphorylation
glycosylation
sumoylation
ubiquitination
|
|
gptkbp:significance
|
target for cancer therapy
target for diabetes therapy
target for metabolic syndrome therapy
|
|
gptkbp:structure
|
heterotetramer
|
|
gptkbp:subunit
|
alpha subunit
beta subunit
|
|
gptkbp:UniProtID
|
P06213
|
|
gptkbp:bfsParent
|
gptkb:receptor_tyrosine_kinase
gptkb:receptor_tyrosine_kinases_(Class_IA)
gptkb:PI3K_(phosphoinositide_3-kinase)
gptkb:IGF2
gptkb:IRS1
|
|
gptkbp:bfsLayer
|
6
|