receptor tyrosine kinases (Class IA)
GPTKB entity
Statements (24)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:activatedBy |
ligand binding
|
| gptkbp:contains |
gptkb:insulin_receptor
gptkb:insulin-like_growth_factor_1_receptor gptkb:insulin_receptor-related_receptor |
| gptkbp:domain |
transmembrane domain
extracellular ligand-binding domain intracellular tyrosine kinase domain |
| gptkbp:dysfunction |
gptkb:cancer
gptkb:diabetes_mellitus |
| gptkbp:function |
cell differentiation
cell survival signal transduction cell growth regulation |
| https://www.w3.org/2000/01/rdf-schema#label |
receptor tyrosine kinases (Class IA)
|
| gptkbp:ligand |
gptkb:insulin
gptkb:insulin-like_growth_factors |
| gptkbp:location |
gptkb:plasma_membrane
|
| gptkbp:mechanismOfAction |
autophosphorylation
|
| gptkbp:pathway |
gptkb:MAPK_signaling_pathway
gptkb:PI3K-Akt_signaling_pathway |
| gptkbp:subclassOf |
gptkb:receptor_tyrosine_kinases
|
| gptkbp:bfsParent |
gptkb:Class_I_PI3K
|
| gptkbp:bfsLayer |
5
|