|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alias
|
gptkb:CD221
gptkb:IGFIR
gptkb:JTK13
|
|
gptkbp:associatedWith
|
gptkb:cancer
insulin resistance
growth disorders
|
|
gptkbp:biologicalProcess
|
cell differentiation
cell survival
cell growth
protein tyrosine kinase activity
apoptosis inhibition
|
|
gptkbp:cellularComponent
|
gptkb:plasma_membrane
|
|
gptkbp:discoveredBy
|
LeRoith D et al.
|
|
gptkbp:encodes
|
gptkb:Insulin-like_growth_factor_1_receptor_protein
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000140443
3480
|
|
gptkbp:expressedIn
|
many tissues
|
|
gptkbp:formsComplexWith
|
gptkb:insulin_receptor
|
|
gptkbp:fullName
|
gptkb:Insulin-like_growth_factor_1_receptor
|
|
gptkbp:function
|
gptkb:receptor_tyrosine_kinase
mediates effects of IGF1 and IGF2
|
|
gptkbp:HGNC_ID
|
gptkb:IGF1R
|
|
gptkbp:highest_expression
|
fetal tissues
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
IGF1R
|
|
gptkbp:inhibitedBy
|
gptkb:linsitinib
gptkb:picropodophyllin
|
|
gptkbp:length
|
1367
|
|
gptkbp:ligand
|
gptkb:IGF1
gptkb:IGF2
|
|
gptkbp:locatedOnChromosome
|
gptkb:19p13.2
19
|
|
gptkbp:molecularWeight
|
155 kDa
|
|
gptkbp:mutationAssociatedWith
|
insulin resistance
growth retardation
|
|
gptkbp:OMIM
|
147370
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
gptkb:Igf1r
|
|
gptkbp:pathway
|
gptkb:MAPK_signaling_pathway
gptkb:PI3K-Akt_signaling_pathway
|
|
gptkbp:PDB
|
3D94
|
|
gptkbp:phosphorylates
|
tyrosine residues
|
|
gptkbp:postTranslationalModification
|
phosphorylation
glycosylation
|
|
gptkbp:RefSeq
|
gptkb:NM_000875
|
|
gptkbp:reviewedBy
|
gptkb:GeneReviews
gptkb:UniProt
|
|
gptkbp:subunit
|
heterotetramer (2 alpha, 2 beta chains)
|
|
gptkbp:UniProtID
|
gptkb:P08069
|
|
gptkbp:bfsParent
|
gptkb:IGF1_receptor
gptkb:Igf2
gptkb:miR-145
gptkb:IGF-1R
gptkb:P08014
gptkb:insulin-like_growth_factor_1_receptor
|
|
gptkbp:bfsLayer
|
7
|