insulin-like growth factor 2

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:protein growth factor
gptkbp:alternativeName	gptkb:IGF-II gptkb:somatomedin_A
gptkbp:binds	gptkb:IGF1_receptor gptkb:IGF2_receptor gptkb:insulin_receptor
gptkbp:biologicalProcess	cell growth apoptosis regulation metabolic regulation
gptkbp:discoveredBy	Daughaday et al.
gptkbp:discoveredIn	1978
gptkbp:encodedBy	gptkb:IGF2_gene
gptkbp:expressedIn	gptkb:skeletal_muscle gptkb:placenta brain liver
gptkbp:foundIn	humans mammals
gptkbp:function	cell differentiation cell proliferation regulation of growth and development
gptkbp:halfLife	10-20 minutes (in plasma)
gptkbp:HGNC_ID	5466
gptkbp:hormoneType	peptide
https://www.w3.org/2000/01/rdf-schema#label	insulin-like growth factor 2
gptkbp:imprintedGene	yes
gptkbp:involvedIn	fetal development tumorigenesis
gptkbp:locatedOnChromosome	gptkb:chromosome_11p15.5_(human)
gptkbp:medicalUse	biomarker for cancer biomarker for growth disorders
gptkbp:molecularWeight	7.5 kDa
gptkbp:mutationAssociatedWith	gptkb:Wilms_tumor gptkb:Beckwith-Wiedemann_syndrome gptkb:Silver-Russell_syndrome
gptkbp:OMIM	147470
gptkbp:orthologIn	gptkb:livestock gptkb:mouse right
gptkbp:PDB	gptkb:1IGL
gptkbp:postTranslationalModification	phosphorylation glycosylation
gptkbp:receptorAffinity	high for IGF2R low for insulin receptor moderate for IGF1R
gptkbp:relatedTo	gptkb:insulin-like_growth_factor_1
gptkbp:sequence	180 amino acids (precursor)
gptkbp:UniProtID	P01344
gptkbp:bfsParent	gptkb:IGF2
gptkbp:bfsLayer	6