|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:Harvey_rat_sarcoma_viral_oncogene_homolog
gptkb:Transforming_protein_p21
|
|
gptkbp:associatedWith
|
gptkb:cancer
gptkb:bladder_cancer
gptkb:Costello_syndrome
head and neck cancer
|
|
gptkbp:conservedIn
|
gptkb:GTP-binding_domain
gptkb:Switch_II_region
gptkb:Switch_I_region
|
|
gptkbp:discoveredBy
|
gptkb:Harold_E._Varmus
gptkb:J._Michael_Bishop
|
|
gptkbp:discoveredIn
|
1982
|
|
gptkbp:encodedBy
|
gptkb:HRAS_gene
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000174775
3265
|
|
gptkbp:family
|
gptkb:Ras_family
|
|
gptkbp:function
|
signal transduction
GTPase activity
|
|
gptkbp:HGNC_ID
|
5173
|
|
gptkbp:interactsWith
|
gptkb:RASA1
gptkb:GRB2
gptkb:PIK3CA
gptkb:RAF1
gptkb:SOS1
|
|
gptkbp:isOncogene
|
true
|
|
gptkbp:KEGGID
|
gptkb:hsa:3265
|
|
gptkbp:length
|
189 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:11p15.5
|
|
gptkbp:location
|
gptkb:plasma_membrane
|
|
gptkbp:molecularWeight
|
21 kDa
|
|
gptkbp:mutationAssociatedWith
|
cellular transformation
constitutive activation
|
|
gptkbp:OMIM
|
190020
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:pathway
|
gptkb:MAPK_signaling_pathway
gptkb:PI3K-Akt_signaling_pathway
gptkb:Ras_signaling_pathway
|
|
gptkbp:PDB
|
gptkb:5P21
4Q21
|
|
gptkbp:postTranslationalModification
|
farnesylation
palmitoylation
phosphorylation
|
|
gptkbp:RefSeq
|
gptkb:NP_005334.1
|
|
gptkbp:structureType
|
gptkb:monomer
|
|
gptkbp:UniProtID
|
gptkb:P01112
|
|
gptkbp:bfsParent
|
gptkb:LET-60_protein
gptkb:Ras85D_protein
|
|
gptkbp:bfsLayer
|
6
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
human HRAS protein
|