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gptkbp:instanceOf
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UniProt accession number
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gptkbp:alternativeName
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gptkb:JNK1
gptkb:c-Jun_N-terminal_kinase_1
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gptkbp:associatedWith
|
gptkb:Alzheimer's_disease
gptkb:cancer
|
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gptkbp:biologicalProcess
|
MAPK cascade
apoptotic process
cellular response to stress
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gptkbp:database
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gptkb:UniProt
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gptkbp:ensembl
|
ENSG00000107643
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gptkbp:Entrez_Gene_ID
|
5599
|
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gptkbp:enzymeClassification
|
gptkb:EC_2.7.11.24
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gptkbp:function
|
protein serine/threonine kinase activity
Serine/threonine-protein kinase involved in stress-activated signaling pathways
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gptkbp:gene
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gptkb:MAPK8
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gptkbp:hasIsoform
|
2
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gptkbp:HGNC_ID
|
6881
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https://www.w3.org/2000/01/rdf-schema#label
|
P45983
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gptkbp:interactsWith
|
gptkb:c-Jun
gptkb:MAP2K4
gptkb:MAP2K7
gptkb:TP53
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gptkbp:lastAnnotationUpdate
|
2022-02-23
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gptkbp:latestReleaseVersion
|
2001-06-01
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gptkbp:length
|
427 amino acids
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gptkbp:locatedOnChromosome
|
gptkb:10q11.22
|
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gptkbp:location
|
gptkb:nucleus
gptkb:cytoplasm
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gptkbp:molecularWeight
|
48 kDa
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gptkbp:organism
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gptkb:Homo_sapiens
9606
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gptkbp:pathway
|
gptkb:MAPK_signaling_pathway
Apoptosis
|
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gptkbp:phosphorylates
|
Thr183
Tyr185
|
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gptkbp:postTranslationalModification
|
Phosphorylation
Ubiquitination
|
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gptkbp:protein_name
|
gptkb:Mitogen-activated_protein_kinase_8
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gptkbp:proteinFamily
|
gptkb:MAP_kinase_family
gptkb:JNK_subfamily
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gptkbp:refersTo
|
gptkb:Mitogen-activated_protein_kinase_8
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gptkbp:RefSeq
|
NP_002740.1
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gptkbp:sequenceStatus
|
Reviewed
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gptkbp:sequenceVersion
|
4
|
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gptkbp:structure
|
Monomer, dimerizes upon activation
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gptkbp:subcellularLocation
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gptkb:Nucleus
gptkb:Cytoplasm
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gptkbp:bfsParent
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gptkb:MAPK9
gptkb:JNK1
gptkb:JNK2
gptkb:MAPK8
gptkb:Mitogen-activated_protein_kinase_8
gptkb:c-Jun_N-terminal_kinase_1
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gptkbp:bfsLayer
|
7
|