|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:component
|
adherens junctions
desmosomes
|
|
gptkbp:discoveredBy
|
gptkb:Masatoshi_Takeichi
|
|
gptkbp:dysregulationAssociatedWith
|
developmental disorders
cancer metastasis
|
|
gptkbp:encodedBy
|
CDH genes
|
|
gptkbp:evolutionaryConserved
|
yes
|
|
gptkbp:expressedIn
|
neurons
endothelial cells
muscle cells
epithelial cells
|
|
gptkbp:firstDescribed
|
1977
|
|
gptkbp:foundIn
|
animals
|
|
gptkbp:function
|
cell adhesion
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
cadherins
|
|
gptkbp:interactsWith
|
catenins
|
|
gptkbp:involvedIn
|
embryonic development
tissue morphogenesis
maintenance of tissue architecture
|
|
gptkbp:medium
|
homophilic cell-cell adhesion
|
|
gptkbp:namedFor
|
calcium-dependent adhesion
|
|
gptkbp:proteinFamily
|
gptkb:CDH1
gptkb:CDH2
gptkb:CDH3
gptkb:CDH5
gptkb:DSC1
gptkb:DSG1
|
|
gptkbp:regulates
|
signal transduction
cell migration
cell polarity
|
|
gptkbp:requires
|
calcium ions
|
|
gptkbp:role
|
wound healing
angiogenesis
tumor suppression
epithelial-mesenchymal transition
synapse formation
|
|
gptkbp:structure
|
cytoplasmic tail
extracellular cadherin repeats
single-pass transmembrane domain
|
|
gptkbp:subclassOf
|
cell adhesion molecules
|
|
gptkbp:type
|
gptkb:E-cadherin
gptkb:N-cadherin
gptkb:VE-cadherin
gptkb:Desmocollins
gptkb:Desmogleins
gptkb:P-cadherin
transmembrane proteins
|
|
gptkbp:bfsParent
|
gptkb:beta-catenin
gptkb:Ctnnb1
gptkb:catenin_(cadherin-associated_protein),_beta_1
|
|
gptkbp:bfsLayer
|
6
|