|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alsoKnownAs
|
gptkb:β-catenin
|
|
gptkbp:component
|
cadherin protein complex
|
|
gptkbp:degradedBy
|
gptkb:proteasome
|
|
gptkbp:discoveredBy
|
Rolf Kemler
|
|
gptkbp:discoveredIn
|
1989
|
|
gptkbp:encodedBy
|
gptkb:CTNNB1_gene
|
|
gptkbp:foundIn
|
gptkb:Homo_sapiens
|
|
gptkbp:function
|
gptkb:Wnt_signaling_pathway
cell adhesion
|
|
gptkbp:GO_term
|
GO:0008284 (positive regulation of cell proliferation)
GO:0005913 (cell-cell adherens junction)
|
|
gptkbp:interactsWith
|
gptkb:APC_protein
gptkb:Axin
gptkb:TCF/LEF_transcription_factors
gptkb:E-cadherin
|
|
gptkbp:involvedIn
|
cell migration
cell fate determination
epithelial-mesenchymal transition
stem cell renewal
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_3p22.1
|
|
gptkbp:location
|
gptkb:cell_membrane
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:molecularWeight
|
~88 kDa
|
|
gptkbp:mutationAssociatedWith
|
colorectal cancer
hepatocellular carcinoma
|
|
gptkbp:OMIM
|
116806
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Drosophila_melanogaster
|
|
gptkbp:PDB
|
1JDH
|
|
gptkbp:postTranslationalModification
|
phosphorylation
ubiquitination
|
|
gptkbp:regulates
|
gptkb:GSK-3β
gptkb:Wnt_ligands
gene transcription
|
|
gptkbp:role
|
embryonic development
tumorigenesis
|
|
gptkbp:structure
|
contains armadillo repeats
|
|
gptkbp:subcellularLocation
|
nuclear chromatin
adherens junction
|
|
gptkbp:UniProtID
|
gptkb:P35222
|
|
gptkbp:bfsParent
|
gptkb:CTNNB1
gptkb:beta-catenin
|
|
gptkbp:bfsLayer
|
8
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Catenin beta-1
|