|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:conservationProgram
|
highly conserved in vertebrates
|
|
gptkbp:discoveredBy
|
gptkb:Bert_Vogelstein
|
|
gptkbp:discoveredIn
|
1991
|
|
gptkbp:domain
|
C-terminal domain
15-amino acid repeats
20-amino acid repeats
SAMP repeats
armadillo repeats
basic domain
|
|
gptkbp:encodedBy
|
gptkb:APC_gene
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:APC
ENSG00000134982
|
|
gptkbp:expressedIn
|
ubiquitous
|
|
gptkbp:expressionHighest
|
gptkb:small_intestine
colon
|
|
gptkbp:fullName
|
gptkb:Adenomatous_polyposis_coli_protein
|
|
gptkbp:function
|
tumor suppressor
regulation of Wnt signaling pathway
regulation of cell migration
regulation of cell adhesion
regulation of microtubule stability
|
|
gptkbp:HGNC_ID
|
583
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
APC protein
|
|
gptkbp:interactsWith
|
gptkb:GSK-3β
gptkb:beta-catenin
microtubules
axin
|
|
gptkbp:locatedOnChromosome
|
5q21-q22
|
|
gptkbp:location
|
gptkb:cell_membrane
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:molecularWeight
|
~310 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:familial_adenomatous_polyposis
colorectal cancer
deletion
insertion
missense mutation
nonsense mutation
frameshift mutation
|
|
gptkbp:OMIM
|
611731
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:PDB
|
3NMW
|
|
gptkbp:postTranslationalModification
|
phosphorylation
sumoylation
ubiquitination
|
|
gptkbp:RefSeq
|
NP_000032.2
|
|
gptkbp:target
|
therapeutic research in cancer
|
|
gptkbp:UniProtID
|
P25054
|
|
gptkbp:bfsParent
|
gptkb:Wnt_signaling_pathway
gptkb:beta-catenin
gptkb:Catenin_beta-1
gptkb:Ctnnb1
gptkb:catenin_(cadherin-associated_protein),_beta_1
|
|
gptkbp:bfsLayer
|
6
|