|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alternativeName
|
gptkb:beta-catenin
gptkb:catenin_(cadherin-associated_protein),_beta_1
|
|
gptkbp:associatedWith
|
gptkb:Wnt_signaling_pathway
colorectal cancer
intellectual disability
hepatocellular carcinoma
cell adhesion
|
|
gptkbp:degradedBy
|
gptkb:GSK3B
gptkb:APC_complex
|
|
gptkbp:discoveredIn
|
1990s
|
|
gptkbp:encodes
|
gptkb:Catenin_beta-1
|
|
gptkbp:Entrez_Gene_ID
|
1499
ENSG00000168036
|
|
gptkbp:expressedIn
|
many tissues
|
|
gptkbp:function
|
cell-cell adhesion
transcription co-activator
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:hasTranscriptVariant
|
multiple
|
|
gptkbp:HGNC_ID
|
2514
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
CTNNB1
|
|
gptkbp:interactsWith
|
gptkb:APC
gptkb:AXIN1
gptkb:TCF7L2
gptkb:E-cadherin
|
|
gptkbp:length
|
781 amino acids
|
|
gptkbp:locatedOnChromosome
|
3p22.1
|
|
gptkbp:molecularWeight
|
85 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:cancer
nonsense
missense
neurodevelopmental disorders
frameshift
|
|
gptkbp:OMIM
|
116806
|
|
gptkbp:orthologInMouse
|
gptkb:Ctnnb1
|
|
gptkbp:phosphorylates
|
Ser33
Ser37
Ser45
Thr41
|
|
gptkbp:product
|
gptkb:beta-catenin
|
|
gptkbp:regulates
|
cell differentiation
cell proliferation
embryonic development
gene expression
|
|
gptkbp:significance
|
tumor suppressor
tumor suppressor (context-dependent)
|
|
gptkbp:subcellularLocation
|
gptkb:cell_membrane
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:UniProtID
|
gptkb:P35222
|
|
gptkbp:bfsParent
|
gptkb:cancer
|
|
gptkbp:bfsLayer
|
4
|