|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
gptkb:DP2
gptkb:DP3
GS
|
|
gptkbp:associatedWith
|
gptkb:familial_adenomatous_polyposis
colorectal cancer
|
|
gptkbp:discoveredBy
|
gptkb:Bert_Vogelstein
|
|
gptkbp:discoveredIn
|
1991
|
|
gptkbp:encodes
|
gptkb:APC_protein
|
|
gptkbp:Entrez_Gene_ID
|
324
|
|
gptkbp:expressedIn
|
gptkb:thyroid
gptkb:cancer
gptkb:skeletal_muscle
gptkb:kidney
gptkb:placenta
gptkb:prostate
gptkb:small_intestine
gptkb:testis
gptkb:thymus
brain
heart
liver
spleen
colon
pancreas
stomach
|
|
gptkbp:fullName
|
gptkb:Adenomatous_polyposis_coli
|
|
gptkbp:function
|
tumor suppressor
|
|
gptkbp:HGNC_ID
|
HGNC:583
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
APC gene
|
|
gptkbp:interactsWith
|
gptkb:Axin
gptkb:GSK3B
gptkb:CTNNB1
gptkb:AURKA
gptkb:beta-catenin
gptkb:EB1
microtubules
|
|
gptkbp:length
|
2843 amino acids
8535 base pairs
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_5
5q21-q22
|
|
gptkbp:mutationAssociatedWith
|
loss-of-function
increased risk of cancer
polyposis
|
|
gptkbp:numberOfExons
|
21
|
|
gptkbp:OMIM
|
611731
|
|
gptkbp:orthologInFruitFly
|
Apc
|
|
gptkbp:orthologInMouse
|
Apc
|
|
gptkbp:orthologInZebrafish
|
apc
|
|
gptkbp:proteinFamily
|
C-terminal domain
15-amino acid repeats
20-amino acid repeats
SAMP repeats
armadillo repeats
basic domain
EB1-binding domain
|
|
gptkbp:regulates
|
gptkb:Wnt_signaling_pathway
apoptosis
cell migration
cell cycle
cell adhesion
|
|
gptkbp:UniProtID
|
P25054
|
|
gptkbp:bfsParent
|
gptkb:Familial_adenomatous_polyposis
gptkb:familial_adenomatous_polyposis
|
|
gptkbp:bfsLayer
|
6
|