Adenomatous polyposis coli

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:tumor_suppressor gptkb:gene
gptkbp:alternativeSplicing	yes
gptkbp:associatedWith	gptkb:familial_adenomatous_polyposis colorectal cancer
gptkbp:discoveredBy	gptkb:Bert_Vogelstein
gptkbp:encodes	gptkb:APC_protein
gptkbp:Entrez_Gene_ID	324
gptkbp:expressedIn	gptkb:peripheral_blood_leukocyte gptkb:thyroid gptkb:cancer gptkb:pituitary_gland gptkb:skeletal_muscle gptkb:adrenal_gland gptkb:kidney gptkb:placenta gptkb:prostate gptkb:small_intestine gptkb:spinal_cord gptkb:testis gptkb:thymus brain heart liver spleen colon pancreas
gptkbp:function	apoptosis cell migration cell adhesion regulation of Wnt signaling pathway
gptkbp:HGNC_ID	583
gptkbp:interactsWith	gptkb:GSK3B gptkb:APC2 gptkb:beta-catenin gptkb:EB1 microtubules axin
gptkbp:length	2843 amino acids
gptkbp:locatedOnChromosome	gptkb:chromosome_5 5q21-q22
gptkbp:mutationAssociatedWith	germline mutation somatic mutation increased cancer risk polyp formation
gptkbp:OMIM	611731
gptkbp:orthologInMouse	Apc
gptkbp:orthologInZebrafish	apc
gptkbp:proteinFamily	15-amino acid repeats 20-amino acid repeats SAMP repeats armadillo repeats basic domain
gptkbp:symbol	gptkb:APC
gptkbp:UniProtID	P25054
gptkbp:bfsParent	gptkb:APC
gptkbp:bfsLayer	6
https://www.w3.org/2000/01/rdf-schema#label	Adenomatous polyposis coli