Adenomatous polyposis coli

URI: https://gptkb.org/entity/Adenomatous_polyposis_coli
GPTKB entity
Statements (58)
Predicate Object
gptkbp:instanceOf gptkb:gene
tumor suppressor
gptkbp:alternativeSplicing yes
gptkbp:associatedWith gptkb:familial_adenomatous_polyposis
colorectal cancer
gptkbp:discoveredBy gptkb:Bert_Vogelstein
gptkbp:encodes gptkb:APC_protein
gptkbp:Entrez_Gene_ID 324
gptkbp:expressedIn gptkb:peripheral_blood_leukocyte
gptkb:thyroid
gptkb:cancer
gptkb:pituitary_gland
gptkb:skeletal_muscle
gptkb:adrenal_gland
gptkb:kidney
gptkb:placenta
gptkb:prostate
gptkb:small_intestine
gptkb:spinal_cord
gptkb:testis
gptkb:thymus
brain
heart
liver
spleen
colon
pancreas
gptkbp:function apoptosis
cell migration
cell adhesion
regulation of Wnt signaling pathway
gptkbp:HGNC_ID 583
https://www.w3.org/2000/01/rdf-schema#label Adenomatous polyposis coli
gptkbp:interactsWith gptkb:GSK3B
gptkb:APC2
gptkb:beta-catenin
gptkb:EB1
microtubules
axin
gptkbp:length 2843 amino acids
gptkbp:locatedOnChromosome gptkb:chromosome_5
5q21-q22
gptkbp:mutationAssociatedWith germline mutation
somatic mutation
increased cancer risk
polyp formation
gptkbp:OMIM 611731
gptkbp:orthologInMouse Apc
gptkbp:orthologInZebrafish apc
gptkbp:proteinFamily 15-amino acid repeats
20-amino acid repeats
SAMP repeats
armadillo repeats
basic domain
gptkbp:symbol gptkb:APC
gptkbp:UniProtID P25054
gptkbp:bfsParent gptkb:APC
gptkbp:bfsLayer 6