|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alsoKnownAs
|
gptkb:uvomorulin
gptkb:E-cadherin
|
|
gptkbp:associatedWith
|
gptkb:hereditary_diffuse_gastric_cancer_syndrome
gptkb:hereditary_lobular_breast_cancer_syndrome
|
|
gptkbp:clinicalTrialPhase
|
yes
|
|
gptkbp:discoveredBy
|
gptkb:Masatoshi_Takeichi
|
|
gptkbp:discoveredIn
|
1977
|
|
gptkbp:encodes
|
gptkb:E-cadherin
|
|
gptkbp:Entrez_Gene_ID
|
999
ENSG00000039068
|
|
gptkbp:expressedIn
|
epithelial tissues
|
|
gptkbp:fullName
|
gptkb:cadherin_1
|
|
gptkbp:function
|
calcium ion binding
cell-cell adhesion
cell adhesion molecule activity
maintenance of epithelial integrity
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:hasTranscriptVariant
|
multiple
|
|
gptkbp:HGNC_ID
|
1748
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
CDH1
|
|
gptkbp:interactsWith
|
gptkb:alpha-catenin
gptkb:p120-catenin
gptkb:beta-catenin
|
|
gptkbp:locatedOnChromosome
|
16q22.1
|
|
gptkbp:lossOfFunctionEffect
|
epithelial-mesenchymal transition
loss of cell adhesion
increased invasiveness
|
|
gptkbp:molecularWeight
|
120 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:hereditary_diffuse_gastric_cancer
gptkb:lobular_breast_cancer
cleft lip and palate
germline
somatic
|
|
gptkbp:numberOfExons
|
16
|
|
gptkbp:OMIM
|
192090
|
|
gptkbp:orthologInFruitFly
|
shooting
|
|
gptkbp:orthologInMouse
|
gptkb:Cdh1
|
|
gptkbp:orthologInZebrafish
|
cdh1
|
|
gptkbp:product
|
cytoplasmic tail
transmembrane protein
extracellular cadherin repeats
single transmembrane domain
|
|
gptkbp:proteinFamily
|
gptkb:cadherin_superfamily
|
|
gptkbp:regulates
|
cell proliferation
cell migration
cell polarity
|
|
gptkbp:roleInCancer
|
tumor suppressor
|
|
gptkbp:UniProtID
|
P12830
|
|
gptkbp:bfsParent
|
gptkb:EGR1
gptkb:Anaphase-Promoting_Complex
gptkb:E-cadherin
gptkb:APC_complex
|
|
gptkbp:bfsLayer
|
6
|