|
gptkbp:instanceOf
|
signaling molecule
|
|
gptkbp:alsoKnownAs
|
gptkb:Wnt_signaling_pathway
|
|
gptkbp:canonical_pathway_involves
|
β-catenin stabilization
|
|
gptkbp:dysregulationAssociatedWith
|
gptkb:cancer
gptkb:bone
colorectal cancer
developmental disorders
fibrosis
|
|
gptkbp:firstDescribed
|
gptkb:Drosophila_melanogaster
|
|
gptkbp:hasComponent
|
gptkb:β-catenin_destruction_complex
gptkb:Frizzled_receptor
gptkb:LRP5/6_co-receptor
Wnt ligand
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Wnt pathway
|
|
gptkbp:importantFor
|
embryonic development
bone formation
neurogenesis
organogenesis
tissue homeostasis
|
|
gptkbp:involves
|
gptkb:APC_protein
gptkb:Axin
gptkb:Dishevelled_proteins
gptkb:Frizzled_receptors
gptkb:GSK-3β
gptkb:TCF/LEF_transcription_factors
gptkb:Wnt_proteins
gptkb:β-catenin
|
|
gptkbp:modulatedBy
|
gptkb:R-spondin
gptkb:sFRP_proteins
gptkb:Tankyrase
gptkb:WIF-1
gptkb:DKK1
Porcupine enzyme
|
|
gptkbp:namedAfter
|
gptkb:Int-1_gene
gptkb:Wingless_gene
|
|
gptkbp:non-canonical_pathway_involves
|
gptkb:Wnt/Ca2+_pathway
planar cell polarity
|
|
gptkbp:regulates
|
cell proliferation
cell migration
cell fate determination
cell polarity
stem cell renewal
|
|
gptkbp:studiedIn
|
cancer research
stem cell biology
regenerative medicine
|
|
gptkbp:subspecies
|
canonical Wnt pathway
non-canonical Wnt pathway
|
|
gptkbp:target
|
monoclonal antibodies
small molecule inhibitors
therapeutic drugs
|
|
gptkbp:bfsParent
|
gptkb:Wnt_signaling_pathway
|
|
gptkbp:bfsLayer
|
6
|