Statements (32)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:alternativeName |
gptkb:Secreted_frizzled-related_protein_family
|
| gptkbp:binds |
gptkb:Frizzled_receptors
gptkb:Wnt_proteins |
| gptkbp:discoveredIn |
1990s
|
| gptkbp:domain |
Frizzled-like cysteine-rich domain
Netrin-like domain |
| gptkbp:foundIn |
humans
mammals vertebrates |
| gptkbp:fullName |
gptkb:Secreted_Frizzled-Related_Proteins
|
| gptkbp:function |
Wnt signaling pathway modulation
antagonist of Wnt proteins |
| https://www.w3.org/2000/01/rdf-schema#label |
sFRP proteins
|
| gptkbp:location |
extracellular space
|
| gptkbp:orthologIn |
gptkb:Frizzled_receptors
|
| gptkbp:proteinFamily |
gptkb:sFRP1
gptkb:sFRP2 gptkb:sFRP3 gptkb:sFRP4 gptkb:sFRP5 |
| gptkbp:regulates |
apoptosis
cell differentiation cell proliferation cell migration |
| gptkbp:role |
gptkb:cancer
gptkb:cardiovascular_disease embryonic development bone disorders fibrosis |
| gptkbp:bfsParent |
gptkb:Wnt_signaling_pathway
|
| gptkbp:bfsLayer |
6
|