|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alternativeName
|
gptkb:SK
gptkb:Dickkopf-1
gptkb:hDkk-1
|
|
gptkbp:associatedWith
|
gptkb:Alzheimer's_disease
gptkb:cancer
gptkb:bone
multiple myeloma
bone formation
rheumatoid arthritis
osteolytic bone lesions
|
|
gptkbp:binds
|
gptkb:LRP5
gptkb:LRP6
|
|
gptkbp:discoveredBy
|
gptkb:Glinka_et_al.
|
|
gptkbp:discoveredIn
|
1998
|
|
gptkbp:encodes
|
gptkb:Dickkopf-related_protein_1
|
|
gptkbp:Entrez_Gene_ID
|
22943
ENSG00000107984
|
|
gptkbp:expressedIn
|
gptkb:placenta
bone tissue
|
|
gptkbp:fullName
|
gptkb:Dickkopf-related_protein_1
|
|
gptkbp:function
|
Wnt signaling pathway inhibitor
|
|
gptkbp:gene
|
gptkb:DKK1
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:GO_term
|
GO:0005576 (extracellular region)
GO:0090090 (negative regulation of canonical Wnt signaling pathway)
|
|
gptkbp:hasTranscriptVariant
|
NM_001018068.2
NM_012242.3
|
|
gptkbp:HGNC_ID
|
HGNC:2899
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
DKK1
|
|
gptkbp:inhibitedBy
|
Wnt/beta-catenin signaling
|
|
gptkbp:length
|
266 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_10
10q11.2
|
|
gptkbp:molecularWeight
|
28 kDa
|
|
gptkbp:OMIM
|
605189
|
|
gptkbp:orthologInMouse
|
gptkb:Dkk1
|
|
gptkbp:pathway
|
gptkb:Wnt_signaling_pathway
cell differentiation
embryonic development
|
|
gptkbp:PDB
|
gptkb:2JTK
|
|
gptkbp:postTranslationalModification
|
glycosylation
disulfide bond formation
|
|
gptkbp:regulates
|
bone mineral density
osteoblast differentiation
|
|
gptkbp:species
|
gptkb:Homo_sapiens
|
|
gptkbp:subcellularLocation
|
secreted
|
|
gptkbp:target
|
therapeutic antibodies
small molecule inhibitors
|
|
gptkbp:UniProtID
|
O94907
|
|
gptkbp:bfsParent
|
gptkb:WNT
gptkb:Wnt_signaling_pathway
|
|
gptkbp:bfsLayer
|
6
|