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gptkbp:instanceOf
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gptkb:protein
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gptkbp:alternativeName
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gptkb:FZD_receptors
gptkb:Frizzled_proteins
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gptkbp:associatedWith
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gptkb:cancer
cell proliferation
cell polarity
developmental processes
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gptkbp:category
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Cell surface receptor
Developmental biology protein
Signal transduction protein
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gptkbp:database
|
gptkb:HGNC:_4032
GeneCards: FZD1
UniProt: FZD1_HUMAN
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gptkbp:discoveredBy
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gptkb:Jeremy_Nathans
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gptkbp:discoveredIn
|
1989
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gptkbp:encodedBy
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gptkb:FZD_genes
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gptkbp:function
|
Wnt signaling pathway receptor
|
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gptkbp:GO_term
|
GO:0016021 (integral component of membrane)
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gptkbp:interactsWith
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gptkb:Dishevelled_proteins
gptkb:Wnt_ligands
gptkb:LRP5/6
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gptkbp:ligand
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gptkb:Wnt_proteins
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gptkbp:location
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gptkb:cell_membrane
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gptkbp:member
|
gptkb:FZD1
gptkb:FZD10
gptkb:FZD2
gptkb:FZD3
gptkb:FZD4
gptkb:FZD5
gptkb:FZD6
gptkb:FZD7
gptkb:FZD8
gptkb:FZD9
|
|
gptkbp:mutationAssociatedWith
|
gptkb:bone
gptkb:retinal_vascular_disease
colorectal cancer
|
|
gptkbp:numberOfMembers
|
10 in humans
|
|
gptkbp:orthologIn
|
gptkb:Danio_rerio
gptkb:Mus_musculus
gptkb:Drosophila_melanogaster
|
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gptkbp:proteinFamily
|
gptkb:G_protein-coupled_receptors
|
|
gptkbp:signalingType
|
gptkb:canonical_Wnt/β-catenin_pathway
non-canonical Wnt pathway
|
|
gptkbp:structure
|
7 transmembrane domains
|
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gptkbp:UniProtID
|
gptkb:Family:_Frizzled
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gptkbp:bfsParent
|
gptkb:Wnt_signaling_pathway
|
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gptkbp:bfsLayer
|
6
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|
https://www.w3.org/2000/01/rdf-schema#label
|
Frizzled receptors
|