β-catenin destruction complex
GPTKB entity
Statements (21)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:component |
gptkb:Axin
gptkb:GSK3β gptkb:APC gptkb:CK1α |
| gptkbp:discoveredIn |
1990s
|
| gptkbp:dysregulationAssociatedWith |
gptkb:cancer
colorectal cancer hepatocellular carcinoma |
| gptkbp:function |
phosphorylation of β-catenin
regulation of β-catenin levels targeting β-catenin for proteasomal degradation targeting β-catenin for ubiquitination |
| https://www.w3.org/2000/01/rdf-schema#label |
β-catenin destruction complex
|
| gptkbp:involvedIn |
gptkb:Wnt_signaling_pathway
|
| gptkbp:location |
gptkb:cytoplasm
|
| gptkbp:regulates |
cell differentiation
cell proliferation gene expression |
| gptkbp:bfsParent |
gptkb:Wnt_signaling_pathway
|
| gptkbp:bfsLayer |
6
|