|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
DVL proteins
Dishevelled homologs
|
|
gptkbp:discoveredIn
|
gptkb:Drosophila
|
|
gptkbp:domain
|
gptkb:DIX_domain
DEP domain
PDZ domain
|
|
gptkbp:encodedBy
|
DVL genes
|
|
gptkbp:firstDescribed
|
1990s
|
|
gptkbp:foundIn
|
animals
|
|
gptkbp:function
|
signal transduction
|
|
gptkbp:interactsWith
|
gptkb:Axin
gptkb:Frizzled_receptors
gptkb:GSK3
gptkb:β-catenin
|
|
gptkbp:involvedIn
|
gptkb:Wnt_signaling_pathway
|
|
gptkbp:involves
|
gptkb:cancer
gptkb:congenital_heart_disease
neurodevelopmental disorders
|
|
gptkbp:member
|
gptkb:DVL1
gptkb:DVL2
gptkb:DVL3
|
|
gptkbp:modulatedBy
|
gptkb:Wnt/Ca2+_pathway
canonical Wnt pathway
non-canonical Wnt pathway
planar cell polarity pathway
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Homo_sapiens
gptkb:Drosophila_melanogaster
|
|
gptkbp:postTranslationalModification
|
phosphorylation
sumoylation
ubiquitination
|
|
gptkbp:proteinFamily
|
gptkb:DVL
|
|
gptkbp:regulates
|
embryonic development
cell polarity
|
|
gptkbp:reviewedBy
|
PMID: 11252954
PMID: 22084306
|
|
gptkbp:subcellularLocation
|
gptkb:nucleus
gptkb:cytoplasm
gptkb:plasma_membrane
|
|
gptkbp:UniProtID
|
gptkb:O14640_(DVL1)
gptkb:O14641_(DVL2)
Q92997 (DVL3)
|
|
gptkbp:bfsParent
|
gptkb:Wnt_signaling_pathway
|
|
gptkbp:bfsLayer
|
6
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Dishevelled proteins
|