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gptkbp:instanceOf
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gptkb:protein
|
|
gptkbp:co-receptor
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gptkb:LRP5
gptkb:LRP6
|
|
gptkbp:discoveredBy
|
gptkb:Harold_Varmus
gptkb:Roel_Nusse
|
|
gptkbp:example
|
gptkb:Wnt1
gptkb:Wnt5a
gptkb:Wnt7a
gptkb:Wnt3a
gptkb:Wnt8
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gptkbp:firstDescribed
|
1982
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gptkbp:foundIn
|
animals
invertebrates
vertebrates
|
|
gptkbp:function
|
cell proliferation
cell migration
cell signaling
stem cell maintenance
cell polarity
regulation of embryonic development
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Wnt proteins
|
|
gptkbp:involvedIn
|
gptkb:Wnt_signaling_pathway
canonical Wnt pathway
non-canonical Wnt pathway
|
|
gptkbp:modulatedBy
|
gptkb:DKK1
gptkb:WIF1
gptkb:sFRP
|
|
gptkbp:mutationAssociatedWith
|
gptkb:cancer
developmental defects
|
|
gptkbp:namedAfter
|
gptkb:Int-1_(mouse_gene)
gptkb:Wingless_(Drosophila_gene)
|
|
gptkbp:numberOfMembers
|
19 in humans
|
|
gptkbp:postTranslationalModification
|
palmitoylation
glycosylation
|
|
gptkbp:proteinFamily
|
gptkb:WNT_gene_family
|
|
gptkbp:recipient
|
gptkb:Frizzled_family_receptors
|
|
gptkbp:relatedTo
|
gptkb:cancer
colorectal cancer
developmental disorders
|
|
gptkbp:role
|
bone formation
organogenesis
tissue regeneration
immune system regulation
neural development
axis formation
hair follicle development
limb development
synapse formation
|
|
gptkbp:secretes
|
gptkb:Wntless_protein
|
|
gptkbp:bfsParent
|
gptkb:Wnt_signaling_pathway
gptkb:Notum
|
|
gptkbp:bfsLayer
|
6
|