|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alias
|
gptkb:DVL
Dsh
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:discoveredIn
|
gptkb:Drosophila_melanogaster
|
|
gptkbp:domain
|
gptkb:DIX_domain
DEP domain
PDZ domain
|
|
gptkbp:encodedBy
|
gptkb:DVL1_gene
gptkb:DVL2_gene
gptkb:DVL3_gene
|
|
gptkbp:firstDescribed
|
1988
|
|
gptkbp:foundIn
|
gptkb:Homo_sapiens
gptkb:Drosophila_melanogaster
|
|
gptkbp:function
|
signal transduction
|
|
gptkbp:interactsWith
|
gptkb:Axin
gptkb:Frizzled_receptor
gptkb:GSK3
gptkb:β-catenin
|
|
gptkbp:involvedIn
|
gptkb:Wnt_signaling_pathway
|
|
gptkbp:locale
|
gptkb:cytoplasm
gptkb:plasma_membrane
|
|
gptkbp:mutationAssociatedWith
|
gptkb:cancer
neural tube defects
developmental defects
|
|
gptkbp:orthologIn
|
gptkb:human
gptkb:mouse
gptkb:zebrafish
|
|
gptkbp:postTranslationalModification
|
phosphorylation
ubiquitination
|
|
gptkbp:proteinFamily
|
gptkb:DVL_family
|
|
gptkbp:regulates
|
embryonic development
cell fate determination
cell polarity
|
|
gptkbp:relatedTo
|
canonical Wnt pathway
non-canonical Wnt pathway
planar cell polarity pathway
|
|
gptkbp:studiedIn
|
model organisms
|
|
gptkbp:UniProtID
|
gptkb:O14640_(DVL1)
gptkb:O14641_(DVL2)
Q92997 (DVL3)
|
|
gptkbp:bfsParent
|
gptkb:Wnt_signaling_pathway
|
|
gptkbp:bfsLayer
|
6
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Dishevelled
|