|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:binds
|
gptkb:Wnt_proteins
|
|
gptkbp:discoveredBy
|
Hsieh et al.
|
|
gptkbp:discoveredIn
|
1999
|
|
gptkbp:downregulatedIn
|
gptkb:neuroblastoma
gptkb:non-small_cell_lung_cancer
gptkb:Wilms_tumor
gptkb:oral_squamous_cell_carcinoma
gptkb:nasopharyngeal_carcinoma
gptkb:Sertoli-Leydig_cell_tumor
gptkb:cancer
gptkb:medulloblastoma
gptkb:Kaposi's_sarcoma
gptkb:alveolar_rhabdomyosarcoma
gptkb:embryonal_rhabdomyosarcoma
gptkb:endometrial_cancer
gptkb:rhabdomyosarcoma
gptkb:retinoblastoma
gptkb:pheochromocytoma
gptkb:Paget's_disease
gptkb:Ewing_sarcoma
gptkb:myxoid_liposarcoma
gptkb:clear_cell_sarcoma
gptkb:desmoplastic_small_round_cell_tumor
gptkb:extraskeletal_myxoid_chondrosarcoma
gptkb:angiosarcoma
gptkb:choriocarcinoma
gptkb:embryonal_carcinoma
gptkb:seminoma
gptkb:teratoma
gptkb:yolk_sac_tumor
colorectal cancer
esophageal cancer
leukemia
melanoma
mesothelioma
multiple myeloma
pancreatic cancer
prostate cancer
testicular cancer
bladder cancer
adrenocortical carcinoma
cholangiocarcinoma
Small Cell Lung Cancer
synovial sarcoma
osteosarcoma
paraganglioma
hepatocellular carcinoma
pleomorphic liposarcoma
gastric cancer
glioma
liposarcoma
pituitary adenoma
renal cell carcinoma
epithelioid sarcoma
Merkel cell carcinoma
basal cell carcinoma
malignant peripheral nerve sheath tumor
malignant fibrous histiocytoma
undifferentiated pleomorphic sarcoma
alveolar soft part sarcoma
dedifferentiated liposarcoma
dysgerminoma
fibrosarcoma
germ cell tumor
granulosa cell tumor
large cell lung cancer
myxofibrosarcoma
salivary gland carcinoma
sebaceous gland carcinoma
spindle cell sarcoma
|
|
gptkbp:encodedBy
|
gptkb:WIF1_gene
|
|
gptkbp:expressedIn
|
various tissues
|
|
gptkbp:fullName
|
gptkb:Wnt_inhibitory_factor_1
|
|
gptkbp:function
|
inhibits Wnt signaling pathway
|
|
gptkbp:gene
|
gptkb:WIF1
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
WIF-1
|
|
gptkbp:locatedOnChromosome
|
12q14
|
|
gptkbp:location
|
extracellular space
|
|
gptkbp:molecularWeight
|
~42 kDa
|
|
gptkbp:organism
|
gptkb:human
gptkb:mouse
|
|
gptkbp:pathway
|
gptkb:Wnt_signaling_pathway
|
|
gptkbp:role
|
tumor suppressor
epigenetically silenced in some cancers
|
|
gptkbp:structure
|
contains WIF domain
|
|
gptkbp:UniProtID
|
gptkb:Q9Y5W5
|
|
gptkbp:bfsParent
|
gptkb:Wnt_pathway
|
|
gptkbp:bfsLayer
|
7
|