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gptkbp:instanceOf
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gptkb:protein
cell surface receptor
|
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gptkbp:alternativeName
|
gptkb:Wnt_receptor
FZD receptor
|
|
gptkbp:associatedWith
|
gptkb:cancer
developmental disorders
|
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gptkbp:binds
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gptkb:Wnt_proteins
|
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gptkbp:discoveredIn
|
1990s
|
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gptkbp:encodedBy
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gptkb:FZD_genes
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gptkbp:function
|
gptkb:Wnt_signaling_pathway
regulation of cell differentiation
regulation of cell proliferation
cell communication
|
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gptkbp:hasMember
|
gptkb:FZD1
gptkb:FZD10
gptkb:FZD2
gptkb:FZD3
gptkb:FZD4
gptkb:FZD5
gptkb:FZD6
gptkb:FZD7
gptkb:FZD8
gptkb:FZD9
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Frizzled receptor
|
|
gptkbp:interactsWith
|
gptkb:Dishevelled_protein
gptkb:LRP5/6
|
|
gptkbp:involvedIn
|
non-canonical Wnt signaling
canonical Wnt signaling
|
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gptkbp:location
|
gptkb:plasma_membrane
|
|
gptkbp:mutationAssociatedWith
|
tumorigenesis
developmental defects
|
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gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Homo_sapiens
gptkb:Drosophila_melanogaster
|
|
gptkbp:regulates
|
embryonic development
gene expression
stem cell maintenance
cell polarity
|
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gptkbp:relatedTo
|
gptkb:GPCR_superfamily
|
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gptkbp:structure
|
seven transmembrane domains
|
|
gptkbp:target
|
therapeutic antibodies
small molecule inhibitors
|
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gptkbp:UniProtID
|
O00144 (FZD9)
O60353 (FZD6)
O75084 (FZD7)
Q13467 (FZD5)
Q14332 (FZD2)
Q9H461 (FZD8)
Q9NPG1 (FZD3)
Q9ULV1 (FZD4)
Q9ULW2 (FZD10)
Q9UP38 (FZD1)
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gptkbp:bfsParent
|
gptkb:Dishevelled
gptkb:Frizzled/LRP5/6_receptor_complex
gptkb:Wnt_pathway
|
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gptkbp:bfsLayer
|
7
|