Statements (31)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:amendedBy |
gptkb:Wnt_proteins
|
| gptkbp:associatedWith |
colorectal cancer
cell signaling hepatocellular carcinoma developmental processes |
| gptkbp:encodedBy |
NOTUM gene
|
| gptkbp:enzymeCommissionNumber |
EC 3.1.1.-
|
| gptkbp:expressedIn |
brain
liver colon |
| gptkbp:foundIn |
gptkb:Homo_sapiens
gptkb:Drosophila_melanogaster |
| gptkbp:function |
gptkb:carboxylesterase
Wnt signaling regulation |
| gptkbp:gene |
NOTUM
|
| gptkbp:GO_term |
GO:0007267 (cell-cell signaling)
GO:0004806 (triglyceride lipase activity) |
| https://www.w3.org/2000/01/rdf-schema#label |
Notum
|
| gptkbp:inhibitedBy |
gptkb:Wnt_signaling_pathway
|
| gptkbp:locatedOnChromosome |
17q25.1 (human)
|
| gptkbp:location |
extracellular space
|
| gptkbp:molecularWeight |
~50 kDa
|
| gptkbp:orthologIn |
Drosophila Notum protein
mouse Notum protein |
| gptkbp:PDB |
4UZQ
|
| gptkbp:removes |
palmitoleic acid from Wnt proteins
|
| gptkbp:structure |
contains alpha/beta hydrolase fold
|
| gptkbp:UniProtID |
Q6P988
|
| gptkbp:bfsParent |
gptkb:Honorspren
|
| gptkbp:bfsLayer |
5
|