|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alias
|
gptkb:SNA
gptkb:SNAH
gptkb:SNAIL
|
|
gptkbp:associatedWith
|
gptkb:cancer
developmental disorders
fibrosis
|
|
gptkbp:discoveredBy
|
gptkb:Ruvkun_and_Finney_(in_C._elegans,_1989)
|
|
gptkbp:encodes
|
gptkb:Snail_family_transcriptional_repressor_1
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000124216
6615
|
|
gptkbp:expressedIn
|
tumor cells
embryonic tissues
mesenchymal cells
|
|
gptkbp:function
|
transcriptional repressor
regulation of epithelial-mesenchymal transition
|
|
gptkbp:hasZincFingerDomain
|
yes
|
|
gptkbp:HGNC_ID
|
gptkb:HGNC:11130
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
SNAI1
|
|
gptkbp:involvedIn
|
gptkb:EMT_(epithelial-mesenchymal_transition)
gastrulation
cancer metastasis
neural crest formation
|
|
gptkbp:length
|
264 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:20q13.2
|
|
gptkbp:molecularWeight
|
29 kDa
|
|
gptkbp:OMIM
|
602150
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInDrosophila
|
gptkb:Dragon
|
|
gptkbp:orthologInMouse
|
gptkb:Snai1
|
|
gptkbp:orthologInZebrafish
|
gptkb:snai1a
|
|
gptkbp:PDB
|
2Y48
|
|
gptkbp:postTranslationalModification
|
phosphorylation
sumoylation
ubiquitination
|
|
gptkbp:proteinFamily
|
gptkb:Snail_superfamily
|
|
gptkbp:regulates
|
gptkb:CDH1
gptkb:hypoxia
gptkb:Wnt_signaling
gptkb:E-box
gptkb:E-cadherin
embryonic development
cell migration
TGF-beta signaling
tumor progression
MAPK signaling
NF-kB signaling
Notch signaling
PI3K/AKT signaling
cell invasion
microRNAs (e.g., miR-34a, miR-30a)
other epithelial markers
|
|
gptkbp:subcellularLocation
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:UniProtID
|
gptkb:O95863
|
|
gptkbp:bfsParent
|
gptkb:EGR1
|
|
gptkbp:bfsLayer
|
6
|