|
gptkbp:instanceOf
|
testicular cancer
germ cell tumor
|
|
gptkbp:canMetastasizeTo
|
lymph nodes
|
|
gptkbp:commonIn
|
Caucasian males
|
|
gptkbp:compatibleWith
|
alpha-fetoprotein (AFP) elevation
|
|
gptkbp:diagnosedBy
|
ultrasound
histopathology
serum tumor markers
|
|
gptkbp:differentialDiagnosis
|
gptkb:embryonal_carcinoma
gptkb:teratoma
gptkb:yolk_sac_tumor
leukemia
|
|
gptkbp:doesNotMetastasizeTo
|
liver (early stages)
|
|
gptkbp:firstDescribed
|
gptkb:Sir_Samuel_Wilks
1879
|
|
gptkbp:histology
|
large cells with clear cytoplasm
prominent nucleoli
fibrous septa with lymphocytic infiltrate
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
seminoma
|
|
gptkbp:ICD-10_code
|
C62
|
|
gptkbp:location
|
gptkb:testis
|
|
gptkbp:notableFor
|
slow growth
radiosensitivity
good response to therapy
|
|
gptkbp:occurredIn
|
gptkb:mediastinum
retroperitoneum
pineal gland
|
|
gptkbp:originatedIn
|
gptkb:germ_cells
|
|
gptkbp:prognosis
|
generally good
high cure rate
|
|
gptkbp:rarelyMetastasizesTo
|
lungs
|
|
gptkbp:riskFactor
|
gptkb:Klinefelter_syndrome
cryptorchidism
family history of testicular cancer
|
|
gptkbp:stainsPositiveFor
|
gptkb:c-KIT_(CD117)
OCT3/4
PLAP
|
|
gptkbp:subspecies
|
classical seminoma
spermatocytic seminoma
|
|
gptkbp:symptom
|
painless testicular mass
|
|
gptkbp:treatment
|
radiation therapy
chemotherapy
orchiectomy
|
|
gptkbp:tumorMarker
|
beta-hCG (sometimes elevated)
placental alkaline phosphatase (PLAP)
|
|
gptkbp:typicalAgeOfOnset
|
15-40 years
|
|
gptkbp:bfsParent
|
gptkb:testicular_germ_cell_tumors
|
|
gptkbp:bfsLayer
|
7
|