|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:ODF
CD254
OPGL
TRANCE
|
|
gptkbp:biologicalProcess
|
immune response regulation
osteoclast differentiation
lymph node development
|
|
gptkbp:encodedBy
|
TNFSF11 gene
|
|
gptkbp:enemyOf
|
osteoprotegerin (OPG)
|
|
gptkbp:expressedIn
|
stromal cells
activated T cells
osteoblasts
|
|
gptkbp:fullName
|
Receptor Activator of Nuclear Factor Kappa-B Ligand
|
|
gptkbp:function
|
activation of osteoclasts
regulation of bone remodeling
|
|
gptkbp:gene
|
TNFSF11
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
RANKL
|
|
gptkbp:locatedOnChromosome
|
gptkb:13q14
|
|
gptkbp:location
|
gptkb:cell_membrane
secreted
|
|
gptkbp:memberOf
|
gptkb:tumor_necrosis_factor_ligand_superfamily
|
|
gptkbp:molecularWeight
|
35 kDa (approximate)
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Rattus_norvegicus
|
|
gptkbp:recipient
|
gptkb:RANK
|
|
gptkbp:significance
|
gptkb:bone
rheumatoid arthritis
bone metastasis
|
|
gptkbp:species
|
gptkb:Homo_sapiens
|
|
gptkbp:target
|
gptkb:denosumab
|
|
gptkbp:UniProtID
|
O14788
|
|
gptkbp:bfsParent
|
gptkb:tumor_necrosis_factor_superfamily
gptkb:osteoclasts
gptkb:TNF_receptor_superfamily
|
|
gptkbp:bfsLayer
|
7
|