|
gptkbp:instanceOf
|
gptkb:protein
cell surface receptor
|
|
gptkbp:alsoKnownAs
|
gptkb:4-1BB
gptkb:TNFRSF9
|
|
gptkbp:associatedWith
|
gptkb:cancer
autoimmune diseases
|
|
gptkbp:cytoplasmicDomain
|
contains TRAF-binding motifs
|
|
gptkbp:discoveredIn
|
1989
|
|
gptkbp:encodedBy
|
gptkb:TNFRSF9_gene
|
|
gptkbp:Entrez_Gene_ID
|
3604
ENSG00000049249
|
|
gptkbp:expressedIn
|
lymphoid tissues
|
|
gptkbp:extracellularDomain
|
cysteine-rich
|
|
gptkbp:foundIn
|
gptkb:natural_killer_cells
dendritic cells
monocytes
activated T cells
|
|
gptkbp:function
|
immune response regulation
costimulatory molecule
|
|
gptkbp:HGNC_ID
|
11927
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
CD137
|
|
gptkbp:involvedIn
|
T cell activation
cytokine production
immune cell proliferation
|
|
gptkbp:ligand
|
gptkb:CD137L
|
|
gptkbp:locatedOnChromosome
|
gptkb:1p36
|
|
gptkbp:memberOf
|
gptkb:tumor_necrosis_factor_receptor_superfamily
|
|
gptkbp:modulatedBy
|
apoptosis
cell survival
inflammation
|
|
gptkbp:OMIM
|
602250
|
|
gptkbp:orthologInMouse
|
Cd137
|
|
gptkbp:structure
|
type I transmembrane protein
|
|
gptkbp:target
|
gptkb:cancer
immunotherapy
|
|
gptkbp:UniProtID
|
gptkb:Q07011
|
|
gptkbp:bfsParent
|
gptkb:tumor_necrosis_factor_receptor_superfamily
gptkb:TNF_receptor_superfamily
|
|
gptkbp:bfsLayer
|
7
|