|
gptkbp:instanceOf
|
gptkb:protein
cell surface receptor
|
|
gptkbp:alsoKnownAs
|
gptkb:APO-1
gptkb:TNFRSF6
gptkb:Fas_receptor
|
|
gptkbp:discoveredIn
|
1989
|
|
gptkbp:domain
|
death domain
|
|
gptkbp:encodedBy
|
gptkb:FAS_gene
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:FAS
|
|
gptkbp:expressedIn
|
many tissues
|
|
gptkbp:formsComplexWith
|
gptkb:death-inducing_signaling_complex_(DISC)
|
|
gptkbp:function
|
induces apoptosis
|
|
gptkbp:HGNC_ID
|
gptkb:HGNC:11920
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
CD95
|
|
gptkbp:interactsWith
|
gptkb:FADD
gptkb:Fas_ligand
gptkb:caspase-8
|
|
gptkbp:involvedIn
|
programmed cell death
immune system regulation
T cell homeostasis
elimination of autoreactive lymphocytes
|
|
gptkbp:ligand
|
gptkb:Fas_ligand_(FasL)
|
|
gptkbp:locatedOnChromosome
|
gptkb:10q23.31
|
|
gptkbp:location
|
gptkb:cell_membrane
|
|
gptkbp:memberOf
|
gptkb:tumor_necrosis_factor_receptor_superfamily
|
|
gptkbp:mutationAssociatedWith
|
gptkb:autoimmune_lymphoproliferative_syndrome
gptkb:cancer
|
|
gptkbp:OMIM
|
134637
|
|
gptkbp:PDB
|
gptkb:3THM
|
|
gptkbp:regulates
|
apoptosis
immune cell homeostasis
|
|
gptkbp:significance
|
gptkb:systemic_lupus_erythematosus
gptkb:graft-versus-host_disease
leukemia
HIV infection
liver failure
autoimmune diseases
cancer progression
hepatitis
immunodeficiency
autoimmunity
solid tumors
apoptosis resistance
immune evasion by tumors
|
|
gptkbp:target
|
immunotherapy
therapeutic antibodies
|
|
gptkbp:UniProtID
|
gptkb:P25445
|
|
gptkbp:bfsParent
|
gptkb:Fas
gptkb:Fas_receptor
|
|
gptkbp:bfsLayer
|
6
|