gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
gptkbp:alternativeName
|
gptkb:Bp50
gptkb:CDW40
gptkb:MGC9013
gptkb:TNFRSF5
|
gptkbp:associatedWith
|
gptkb:hyper-IgM_syndrome
autoimmune diseases
immunodeficiency
|
gptkbp:biologicalProcess
|
signal transduction
inflammatory response
receptor activity
immune system process
|
gptkbp:cellularComponent
|
gptkb:plasma_membrane
|
gptkbp:discoveredBy
|
gptkb:Edward_A._Clark
|
gptkbp:encodedBy
|
gptkb:CD40_gene
|
gptkbp:Entrez_Gene_ID
|
958
ENSG00000101017
|
gptkbp:expressedIn
|
gptkb:B_lymphocytes
dendritic cells
macrophages
endothelial cells
fibroblasts
epithelial cells
|
gptkbp:firstDescribed
|
1985
|
gptkbp:foundIn
|
gptkb:Homo_sapiens
|
gptkbp:function
|
B cell activation
immune response regulation
T cell-dependent immunoglobulin class switching
|
gptkbp:geneType
|
protein-coding
|
gptkbp:HGNC_ID
|
11919
|
https://www.w3.org/2000/01/rdf-schema#label
|
CD40
|
gptkbp:interactsWith
|
gptkb:TRAF_proteins
gptkb:CD40_ligand
|
gptkbp:length
|
277
|
gptkbp:ligand
|
gptkb:CD40L
|
gptkbp:locatedOnChromosome
|
chromosome 20
20q13.12
|
gptkbp:memberOf
|
gptkb:tumor_necrosis_factor_receptor_superfamily
|
gptkbp:molecularWeight
|
32 kDa
|
gptkbp:mutationAssociatedWith
|
immunodeficiency with hyper-IgM
|
gptkbp:OMIM
|
109535
|
gptkbp:orthologIn
|
gptkb:Bos_taurus
gptkb:Mus_musculus
gptkb:Rattus_norvegicus
|
gptkbp:target
|
immunotherapy
therapeutic antibodies
|
gptkbp:UniProtID
|
P25942
|
gptkbp:bfsParent
|
gptkb:immunoglobulin_superfamily
gptkb:tumor_necrosis_factor_receptor_superfamily
gptkb:TNF_receptor_superfamily
|
gptkbp:bfsLayer
|
7
|