CD40

GPTKB entity

Statements (52)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkb:gene
gptkbp:alternativeName gptkb:Bp50
gptkb:CDW40
gptkb:MGC9013
gptkb:TNFRSF5
gptkbp:associatedWith gptkb:hyper-IgM_syndrome
autoimmune diseases
immunodeficiency
gptkbp:biologicalProcess signal transduction
inflammatory response
receptor activity
immune system process
gptkbp:cellularComponent gptkb:plasma_membrane
gptkbp:discoveredBy gptkb:Edward_A._Clark
gptkbp:encodedBy gptkb:CD40_gene
gptkbp:Entrez_Gene_ID 958
ENSG00000101017
gptkbp:expressedIn gptkb:B_lymphocytes
dendritic cells
macrophages
endothelial cells
fibroblasts
epithelial cells
gptkbp:firstDescribed 1985
gptkbp:foundIn gptkb:Homo_sapiens
gptkbp:function B cell activation
immune response regulation
T cell-dependent immunoglobulin class switching
gptkbp:geneType protein-coding
gptkbp:HGNC_ID 11919
https://www.w3.org/2000/01/rdf-schema#label CD40
gptkbp:interactsWith gptkb:TRAF_proteins
gptkb:CD40_ligand
gptkbp:length 277
gptkbp:ligand gptkb:CD40L
gptkbp:locatedOnChromosome chromosome 20
20q13.12
gptkbp:memberOf gptkb:tumor_necrosis_factor_receptor_superfamily
gptkbp:molecularWeight 32 kDa
gptkbp:mutationAssociatedWith immunodeficiency with hyper-IgM
gptkbp:OMIM 109535
gptkbp:orthologIn gptkb:Bos_taurus
gptkb:Mus_musculus
gptkb:Rattus_norvegicus
gptkbp:target immunotherapy
therapeutic antibodies
gptkbp:UniProtID P25942
gptkbp:bfsParent gptkb:immunoglobulin_superfamily
gptkb:tumor_necrosis_factor_receptor_superfamily
gptkb:TNF_receptor_superfamily
gptkbp:bfsLayer 7