|
gptkbp:instanceOf
|
cytokine
|
|
gptkbp:abbreviation
|
gptkb:TNF
|
|
gptkbp:associatedWith
|
psoriasis
septic shock
rheumatoid arthritis
inflammatory bowel disease
|
|
gptkbp:category
|
immune system protein
signaling protein
pro-inflammatory cytokine
|
|
gptkbp:discoveredBy
|
gptkb:Lloyd_J._Old
|
|
gptkbp:discoveredIn
|
1975
|
|
gptkbp:encodedBy
|
gptkb:TNF_gene
|
|
gptkbp:Entrez_Gene_ID
|
7124
|
|
gptkbp:foundIn
|
humans
mice
|
|
gptkbp:function
|
apoptosis induction
induction of inflammation
inhibition of tumorigenesis
inhibition of viral replication
regulation of immune cells
|
|
gptkbp:GO_term
|
GO:0006954 (inflammatory response)
|
|
gptkbp:HGNC_ID
|
11892
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Tumor Necrosis Factor
|
|
gptkbp:inducedBy
|
apoptosis
fever
inflammation
cachexia
|
|
gptkbp:inhibitedBy
|
gptkb:thalidomide
pentoxifylline
|
|
gptkbp:locatedOnChromosome
|
gptkb:6p21.3
|
|
gptkbp:MeSH_ID
|
D016133
|
|
gptkbp:molecularWeight
|
17 kDa (monomer)
|
|
gptkbp:OMIM
|
191160
|
|
gptkbp:PDB
|
gptkb:2TNF
|
|
gptkbp:producedBy
|
gptkb:natural_killer_cells
gptkb:T_cells
macrophages
|
|
gptkbp:recipient
|
gptkb:TNFR1
gptkb:TNFR2
|
|
gptkbp:relatedTo
|
gptkb:TNF-alpha
gptkb:TNF-beta
|
|
gptkbp:structure
|
homotrimer
|
|
gptkbp:target
|
gptkb:etanercept
gptkb:golimumab
gptkb:infliximab
gptkb:certolizumab_pegol
gptkb:adalimumab
|
|
gptkbp:UniProtID
|
gptkb:P01375
|
|
gptkbp:bfsParent
|
gptkb:TNF
|
|
gptkbp:bfsLayer
|
7
|